Browse by type "cumulativeThesis"
Now showing items 1-19 of 19
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Misp53 mutation-specific oncogenic transcription factor complexes in PDAC progression
(2024-07-02)Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second-leading cause of cancer related death by 2040 with a 5-year survival rate of only 11%. PDAC aggressiveness is attributed to its high heterogeneity ... -
3D imaging of immune cell reaction in pancreatic cancer organoids: the response to a nanovaccine therapy
(2024-06-27)This PhD thesis explored the use of patient-derived organoids (PDOs) obtained from tumor tissue, to address research limitations and therapeutic challenges in pancreatic ductal adenocarcinoma (PDAC), characterized by a ... -
Defining the Role of Chromatin Remodeling Complexes in Control of Master Transcription Factor Networks in Pancreatic Cancer Subtype Switch
(2023-10-19)Pancreatic ductal adenocarcinoma (PDAC) is a highly heterogeneous disease characterized by a dismal prognosis of 11%, projected to be the second-leading cause of cancer-related death by 2040. This urgent clinical challenge ... -
Modulation of HSF1 activity by p53 and its impact in cancer therapies
(2023-07-13)The tumor suppressor p53 (TP53) is mutated in ~70 % of colorectal cancer (CRC) cases. Of these cases, approximately 80 % undergo subsequent p53 loss-of-heterozygosity (p53LOH), losing the remaining wildtype p53 (WTp53) ... -
Stereoselectivity in Drug Membrane Transport by Solute Carriers (SLCs)
(2023-07-10)About 50% of all small molecule drugs are racemic mixtures of usually two stereoisomers. In the living organism, these drugs interact with a mostly chiral environment of unichiral amino acids, sugars, hormones, and other ... -
In vivo application of CRISPR/Cas9 mediated gene re-expression in the failing mouse and human myocardium
(2022-11-17)Transcriptional adaptation in cardiomyocytes precedes cellular deterioration and functional decline upon myocardial stress and damage resulting in heart failure progression. The re-activation of WNT/β-catenin (CTNNB1) ... -
Interfering with critical steps of the viral replication cycle to diminish SARS-CoV-2 propagation
(2022-10-07)The ongoing COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has so far infected more than 0.5 billion people worldwide, with at least 6.3 million deaths, and constitutes one of the largest global health ... -
Gene-expression control in early and late-onset dementia
(2022-10-05)Mutations in genes that control epigenetic gene expression, especially the machinery that controls Histone 3 lysine 4 (H3K4me) methylation, are over-represented in intellectual disability disorders. It is mediated by both ... -
Pre-Clinical Assessment of Cardiac and Lung Fibrosis Using Next Generation Imaging Modalities
(2022-03-08)Fibrosis, defined as an excessive deposition of connective tissue components causing disruption of the physiological architecture and organ malfunction, is commonly associated with high morbidity and mortality. The global ... -
MCL-1, BCL-xL and Casp-3 as key regulators in thymus homeostasis and thymic epithelial tumors
(2021-12-23)As a primary lymphatic organ, the thymus is responsible for T cell development and the establishment of the adaptive immune system. The homeostasis and proper function of the thymus epithelium require the strict regulation ... -
Investigating the Mechanistic role of Ykt6 in Wnt Trafficking and Cell cycle Progression
(2021-09-28)Ykt6 is an evolutionarily conserved R-SNARE that mediates vesicle fusion events at diverse cellular compartments of secretory, endocytic and autophagy pathways. It is known to be required for the secretion of Wnts on ... -
Immunotherapy of solid tumors: multimodal imaging strategies for chimeric antigen receptor T cell tracking in the tumor microenvironment
(2021-08-02)Immunotherapy is an emerging building block of modern oncology, after chimeric antigen receptor (CAR) T cells demonstrated groundbreaking survival rates in hematological malignancies. However, therapy success in more common ... -
HSP90-stabilized proteins as therapeutic targets in cancer
(2021-06-25)Although cancer is among the most common causes of death worldwide, successful treatment options for most cancer entities remain elusive, raising the need for novel therapies. One attractive target of current drug candidates ... -
The role of histone 2B monoubiquitination (H2Bub1) in HER2-driven mammary carcinoma
(2021-03-25)Breast cancer (BC) is the most frequent tumor entity in women worldwide with a high chance of therapeutic response in early- and non-metastatic disease stage. Despite the advent of HER2-specific targeted therapies, a ... -
Cholesterol metabolism in mouse models of Multiple Sclerosis
(2020-12-07)The primary origin of brain cholesterol is de novo synthesis due to limited entry peripheral cholesterol across the blood-brain barrier (BBB). Most if not all brain cells contribute to central nervous system (CNS) cholesterol ... -
Targeting cell invason signaling to impede breast cancer metastasis
(2020-02-25)Breast cancer cell invasion is the initial step of the invasion-metastatic cascade, and approximately 90 % of all cancer-related deaths are due to currently incurable cancer metastasis (1). Unique features of tumor ... -
Targeting MDM2, the antagonist of the tumor suppressor p53
(2018-09-19)p53 is one of the most extensively studied tumor suppressor proteins, and its gene is mutated in 50% of human cancers. Stress signals activate p53 and its transcriptional machinery which lead to cell-cycle arrest, apoptosis ... -
Induced pluripotent stem cells from patients with hypoplastic left heart syndrome (HLHS) as a model to study functional contribution of endothelial-mesenchymal transition (EndMT) in HLHS
(2016-11-30)Hypoplastic left heart syndrome (HLHS) is one of the most lethal congenital heart diseases (CHD) and its pathological mechanism remains unclear. Endocardial fibroelastosis (EFE) is a hallmark of HLHS which impairs myocardial ... -
Cardiac and fibroblastic properties after HIF-1α stabilization
(2015-06-01)The cellular oxygen sensing prolyl-4-hydroxylase domain proteins (PHDs) are essential regulators of the α-subunit of hypoxia-inducible transcription factors (HIFs) which are known to induce a variety of genes affecting ...