Pluripotency of multipotent adult germ-line stem cells: analysis of apoptotic and epigenetic features

Pluripotenz der multipotenten adulten Keimstammzellen: Analyse der apoptotischer und epigenetischer Merkmale

by Tatjana Khromov
Doctoral thesis
Date of Examination:2011-11-29
Date of issue:2012-05-10
Advisor:Prof. Dr. Dr. Wolfgang Engel
Referee:Prof. Dr. Wolfgang Engel
Referee:Prof. Dr. Sigrid Hoyer-Fender
Persistent Address: http://dx.doi.org/10.53846/goediss-1458

 

 

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Abstract

English

Pluripotency is the potential of cells to proliferate incessantly (self-renewal) and to develop into all cell types of the three germ layers as well as to the germ line. Recently established multipotent adult Germ-line Stem Cell (maGSC) lines are pluripotent cells derived from the unipotent Spermatogonial Stem Cells (SSCs) which acquire Embryonic Stem Cells (ESCs) properties in vitro. Since pluripotent maGSCs can have therapeutic potential in regenerative medicine by replacing the ethical problematic ESCs, several groups have studied the similarity of these cells to the “gold standard of pluripotency
Keywords: Stem cells; Germ cells; ES cells; maGSC; Apoptosis; Epigentics
Schlagwörter: Stammzellen; Keimzellen; Apoptosen; Epigenetik; ES Zellen; maGS Zellen
 
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