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Untersuchungen zur Regulation der Zelladhäsion durch PHD2 in Tumorzellen

Investigation on the role of PHD2 in the regulation of cell adhesion in tumor cells

Moritz Thomas Schnelle
Doctoral thesis
Date of Examination: 2012-08-14
Date of issue: 2012-07-24
Advisor: Katschinski, Dörthe Prof. Dr.
Referee: Katschinski, Dörthe Prof. Dr.
Referee: Dobbelstein, Matthias Prof. Dr.
Referee: Oppermann, Martin Prof. Dr.

Persistent Address: http://hdl.handle.net/11858/00-1735-0000-000D-EFE8-8

 

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Abstract

English

The hypoxia-inducible factor 1 (HIF-1) is a transcription factor, which is stabilized under hypoxic conditions. It consists of the HIF-1β- as well as of one of three known HIF-α-subunits. One of its
Keywords: hypoxia; PHD2; HIF-1α; cell adhesion; metastasation; SPARC; SPP1; cofilin
Schlagwörter: Hypoxie; PHD2; HIF-1α; Zelladhäsion; Metastasierung; SPARC; SPP1; Cofilin
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