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dc.contributor.advisor Fischer, André Prof. Dr. de
dc.contributor.author Kerimoglu, Cemil de
dc.date.accessioned 2012-06-06T18:34:54Z de
dc.date.accessioned 2013-01-18T14:23:45Z de
dc.date.available 2013-01-30T23:51:09Z de
dc.date.issued 2012-06-06 de
dc.identifier.uri http://hdl.handle.net/11858/00-1735-0000-000D-F0B4-8 de
dc.format.mimetype application/pdf de
dc.language.iso eng de
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/ de
dc.title Role of Histone Methylation in Cognition and Effects of Different Durations of Environmental Enrichment on Learning and Memory de
dc.type doctoralThesis de
dc.title.translated Role of Histone Methylation in Cognition and Effects of Different Durations of Environmental Enrichment on Learning and Memory de
dc.contributor.referee Fischer, André Prof. Dr. de
dc.date.examination 2012-04-16 de
dc.subject.dnb 500 Naturwissenschaften de
dc.subject.gok RA 000 de
dc.description.abstracteng Part 1 Formation of stable long-term memories requires novel gene expression, and chromatin modifications have been shown to be involved in mediating the de novo gene expression which is necessary for memory formation. Although the role of histone acetylation and different histone deacetylases (HDACs) and histone acetyltransferases (HATs) in learning and memory has been studied quite extensively, the knowledge concerning the role of histone methylation – another important histone modification – in learning and memory is lacking. I have characterized the transgenic mouse line in which the Mll2 gene is conditionally knocked down at adult stage in the forebrain excitatory neurons by the Cre-LoxP system, with Cre recombinase being expressed under CamKII promoter in order to ensure recombination specifically in forebrain glutamatergic neurons knock-out mice being denoted as “F/F CKII de
dc.contributor.coReferee Stühmer, Walter Prof. Dr. de
dc.contributor.thirdReferee Fischle, Wolfgang Prof. Dr. de
dc.subject.topic Göttingen Graduate School for Neurosciences and Molecular Biosciences (GGNB) de
dc.subject.ger Mll2 de
dc.subject.ger Histone Methylierung de
dc.subject.ger Lernen de
dc.subject.ger Gedächtnis de
dc.subject.eng Mll2 de
dc.subject.eng Histone Methylation de
dc.subject.eng Learning de
dc.subject.eng Memory de
dc.subject.bk 30.00 de
dc.identifier.urn urn:nbn:de:gbv:7-webdoc-3545-7 de
dc.identifier.purl webdoc-3545 de
dc.affiliation.institute Göttinger Graduiertenschule für Neurowissenschaften und Molekulare Biowissenschaften (GGNB) de
dc.identifier.ppn 737899395 de

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