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Sec1p/Munc18 (SM) proteins and their role in regulating secretion in Saccharomyces cerevisiae and Caenorhabditis elegans a comparative approach

Sec1p/Munc18 (SM) proteine und deren Rolle in der Sekretionsregulierung in Saccharomyces cerevisiae und Caenorhabditis elegans -eine vergleichende Studie

Iraheta, Raul Emilio
Dissertation
Angenommen am: 2012-11-20
Erschienen: 2013-01-04
Betreuer: Fasshauer, Dirk Prof. Dr.
Gutachter: Fasshauer, Dirk Prof. Dr.
Gutachter: Ficner, Ralf Prof. Dr.
Gutachter: Wahl, Markus Prof. Dr.

Zum Verlinken/Zitieren: http://hdl.handle.net/11858/00-1735-0000-000D-F0CC-3

 

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Zusammenfassung

Englisch

The members of the Sec1p/Munc18 (SM) family of proteins are indispensible regulatory elements that act at the post-docking step prior to fusion; they exert their function mainly through their interaction to the Qa-SNAREs (Syntaxins). Although studies have shown a high degree of structural homology, different binding modes have been proposed. In the case of the neuronal Munc18-1, an affinity towards a “close conformation
Keywords: ITC; Syntaxin; SNAREs; Membrane Fusion; Neuronal Secretion; Sec1/Munc18; Biochemitry; Protein-Protein Interactions
Schlagwörter: ITC; Syntaxin; SNAREs; Membrane Fusion; Neuronal Secretion; Sec1/Munc18; Biochemitry; Protein-Protein Interactions
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