Sec1p/Munc18 (SM) proteins and their role in regulating secretion in Saccharomyces cerevisiae and Caenorhabditis elegans a comparative approach

Sec1p/Munc18 (SM) proteine und deren Rolle in der Sekretionsregulierung in Saccharomyces cerevisiae und Caenorhabditis elegans -eine vergleichende Studie

by Raul Emilio Iraheta
Doctoral thesis
Date of Examination:2012-11-20
Date of issue:2013-01-04
Advisor:Prof. Dr. Dirk Fasshauer
Referee:Prof. Dr. Dirk Fasshauer
Referee:Prof. Dr. Ralf Ficner
Referee:Prof. Dr. Markus Wahl
Persistent Address: http://dx.doi.org/10.53846/goediss-3160

 

 

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Abstract

English

The members of the Sec1p/Munc18 (SM) family of proteins are indispensible regulatory elements that act at the post-docking step prior to fusion; they exert their function mainly through their interaction to the Qa-SNAREs (Syntaxins). Although studies have shown a high degree of structural homology, different binding modes have been proposed. In the case of the neuronal Munc18-1, an affinity towards a “close conformation
Keywords: ITC; Syntaxin; SNAREs; Membrane Fusion; Neuronal Secretion; Sec1/Munc18; Biochemitry; Protein-Protein Interactions
Schlagwörter: ITC; Syntaxin; SNAREs; Membrane Fusion; Neuronal Secretion; Sec1/Munc18; Biochemitry; Protein-Protein Interactions
 
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