Analyse und Charakterisierung regulatorischer Vorgänge in Bacillus licheniformis

Analysis and characterisation of regulatory events in Bacillus licheniformis

by Sascha Dietrich
Doctoral thesis
Date of Examination:2015-01-14
Date of issue:2015-05-08
Advisor:Dr. Heiko Liesegang
Referee:PD Dr. Rolf Daniel
Referee:Prof. Dr. Edgar Wingender
Referee:Prof. Dr. Burkhard Morgenstern
Referee:Oliver Valerius
Referee:Prof. Dr. Kai Heimel
Referee:PD Dr. Wilfried Kramer
Persistent Address: http://dx.doi.org/10.53846/goediss-5059

 

 

Files in this item

Name:Dissertation_SaschaDietrich_Pub_ediss.pdf
Size:6.27Mb
Format:PDF
Description:Dissertation Sascha Dietrich

The following license files are associated with this item:

Abstract

English

Analysis of RNA-Seq data in a genome context sensitive approach to identify known and novel RNA-regulatory elements and events applied by Bacillus licheniformis DSM13 to adapt its physiology to a productive fermentation. The combination of the transcriptional activity with the genomic context allows novel insights into the way Bacillus licheniformis DSM13 uses its genomic capabilities in an industrial production environment. For the purpose of analysing this RNA-Seq data, a bioinformatic tool called TraV (Transcriptome Viewer) has been developed that allows the comparative analysis of multiple transcriptome datasets in parallel. This approach allows the identification of changing transcriptional behaviour under different or changing growth conditions.
Keywords: Transcriptomics; Bacillus licheniformis DSM13; RNA-Seq; Regulatory RNAs
 
Statistik