Analyse und Charakterisierung regulatorischer Vorgänge in Bacillus licheniformis
Analysis and characterisation of regulatory events in Bacillus licheniformis
von Sascha Dietrich
Datum der mündl. Prüfung:2015-01-14
Erschienen:2015-05-08
Betreuer:Dr. Heiko Liesegang
Gutachter:PD Dr. Rolf Daniel
Gutachter:Prof. Dr. Edgar Wingender
Gutachter:Prof. Dr. Burkhard Morgenstern
Gutachter:Oliver Valerius
Gutachter:Prof. Dr. Kai Heimel
Gutachter:PD Dr. Wilfried Kramer
Dateien
Name:Dissertation_SaschaDietrich_Pub_ediss.pdf
Size:6.27Mb
Format:PDF
Description:Dissertation Sascha Dietrich
Zusammenfassung
Englisch
Analysis of RNA-Seq data in a genome context sensitive approach to identify known and novel RNA-regulatory elements and events applied by Bacillus licheniformis DSM13 to adapt its physiology to a productive fermentation. The combination of the transcriptional activity with the genomic context allows novel insights into the way Bacillus licheniformis DSM13 uses its genomic capabilities in an industrial production environment. For the purpose of analysing this RNA-Seq data, a bioinformatic tool called TraV (Transcriptome Viewer) has been developed that allows the comparative analysis of multiple transcriptome datasets in parallel. This approach allows the identification of changing transcriptional behaviour under different or changing growth conditions.
Keywords: Transcriptomics; Bacillus licheniformis DSM13; RNA-Seq; Regulatory RNAs