C-H and C-C Activation by Cobalt and Ruthenium Catalysis
von Marc Philipp Moselage
Datum der mündl. Prüfung:2017-11-15
Erschienen:2017-12-18
Betreuer:Prof. Dr. Lutz Ackermann
Gutachter:Prof. Dr. Lutz Ackermann
Gutachter:Prof. Dr. Franc Meyer
Gutachter:Prof. Dr. Dietmar Stalke
Gutachter:Prof. Dr. Manuel Alcarazo
Gutachter:Dr. Shoubhik Das
Gutachter:Dr. Franziska Thomas
Dateien
Name:Thesis_Moselage.pdf
Size:8.39Mb
Format:PDF
Zusammenfassung
Englisch
The thesis contents methods for the selective activation and functionalization of C–H and C–C bonds, among the most abundant bonds in organic molecules. In particular, earth-abundant and cost-effective cobalt complexes were utilized for C–H activation reactions, namely C¬–H alkenylation with alkenyl esters and C–H allylation with allyl esters. Furthermore, the concept of cobalt-catalyzed C–H activation could be applied in the synthesis of indoles, as an important class of heterocycles. Apart from C–H activation, a methodology of the functionalization of C–C bonds was discovered using ruthenium catalysis. In this project, a C–C arylation in a decarboxylative and decarbamoylative fashion was accomplished. This was extended to a decarboxylative alkylation by C–C and C–C/C–H bond cleavage.
Keywords: C-H Activation; C-C Activation; Cobalt; Ruthenium; Alkenylation; Allylation; Indole Synthesis; Arylation; meta-selectivity