Ruthenium(II)-Catalyzed C-H Arylations of Arenes

by Jonathan Hubrich
Doctoral thesis
Date of Examination:2016-09-30
Date of issue:2016-10-10
Advisor:Prof. Dr. Lutz Ackermann
Referee:Prof. Dr. Lutz Ackermann
Referee:Dr. Alexander Breder
Persistent Address: http://dx.doi.org/10.53846/goediss-5885

 

 

Files in this item

Name:Dissertation_Jonathan Hubrich_web.pdf
Size:4.37Mb
Format:PDF

The following license files are associated with this item:

Abstract

English

The goal of this work was to devise environmentally friendly and cost-effective novel concepts for the efficient synthesis of biaryl units as core structure in biologically active compounds, which are of great importance to the agrochemical and pharmaceutical industries. Transition metal-catalyzed direct functionalization processes of otherwise inert C‒H bonds emerged as a more sustainable alternative to the classically used cross-coupling reactions for the synthesis of biaryls. For this reason, the research was focused on the development of novel methods for efficient and selective direct C‒H transformations to construct biaryl scaffolds in an atom- and step-economical manner.
Keywords: ruthenium; arylation; C-H activation; bioactive compounds; biaryl
 
Statistik