dc.contributor.advisor | Ehrenreich, Hannelore Prof. Dr. Dr. | |
dc.contributor.author | Oliveira, Bárbara | |
dc.date.accessioned | 2018-06-15T09:30:26Z | |
dc.date.available | 2018-06-15T09:30:26Z | |
dc.date.issued | 2018-06-15 | |
dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-002E-E423-6 | |
dc.identifier.uri | http://dx.doi.org/10.53846/goediss-6915 | |
dc.language.iso | eng | de |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject.ddc | 610 | de |
dc.title | Genetic and autoimmune modulators of brain function in neuropsychiatric illness and health | de |
dc.type | doctoralThesis | de |
dc.contributor.referee | Zimmermann, Wolfram-Hubertus Prof. Dr. | |
dc.date.examination | 2018-04-17 | |
dc.description.abstracteng | In the present thesis, the synergetic interaction between the nervous and immune
systems and the potential pathological outcomes mediated by autoimmune processes
targeting the brain was addressed, with a particular focus on autoantibodies targeting
NMDAR.
The first two projects were designed to understand the role of these autoantibodies beyond
this pathological condition and gain insight to its effects upon access to the brain.
Specifically, Project I aimed at (i) determining the functional properties of NMDAR-ABs of
different isotypes; for this purpose a new assay employing human induced pluripotent stem
cell-derived neurons was developed. (ii) Identifying which NMDAR epitopes are recognized
by these autoantibodies. Project II focused on (i) determining if these NMDAR-AB are
present and functional in other mammal species; (ii) assessing the protective role of the BBB
and the effects of endogenously produced NMDAR-AB on the brain, in the presence of an
open BBB.
Additionally, I have briefly mentioned that disruption of the balance between excitation and
inhibition in the brain can contribute to brain diseases as autism and schizophrenia. The
contributors for such disruption are not completely understood and might have a common
ground between diseases. In Project III, we focused on dissecting the relationship between
the severity of autistic traits in schizophrenic patients and imbalances in excitation and
inhibition. Specifically, using transcranial magnetic stimulation (TMS), we aimed at
determining if individuals with low severity of autistic traits and individuals with high severity
of autistic traits would differ in terms of glutamatergic or GABAergic neurotransmission. | de |
dc.contributor.coReferee | Wienands, Jürgen Prof. Dr. | |
dc.contributor.thirdReferee | Nave, Klaus-Armin Prof. Dr. | |
dc.contributor.thirdReferee | Brose, Nils Prof. Dr. | |
dc.contributor.thirdReferee | Heinrich, Ralf Prof. Dr. | |
dc.contributor.thirdReferee | Wojcik, Sonja Dr. | |
dc.subject.eng | Autoantibodies | de |
dc.subject.eng | NMDAR | de |
dc.subject.eng | Autoimmunity | de |
dc.subject.eng | Neuroimmunology | de |
dc.identifier.urn | urn:nbn:de:gbv:7-11858/00-1735-0000-002E-E423-6-0 | |
dc.affiliation.institute | Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und molekulare Biowissenschaften (GGNB) | de |
dc.subject.gokfull | Biologie (PPN619462639) | de |
dc.identifier.ppn | 1024638278 | |