Zytostatisches Potenzial neuer Uracilderivate

Cytostatic potential of new uracilderivatives

by Antje Britta Hofmann
Doctoral thesis
Date of Examination:2018-12-05
Date of issue:2018-11-29
Advisor:Prof. Dr. Hans Jürgen Steinfelder
Referee:Prof. Dr. Hans Jürgen Steinfelder
Referee:Prof. Dr. Dieter Kube
Persistent Address: http://dx.doi.org/10.53846/goediss-7162

 

 

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Abstract

English

In medicine uracil derivatives are already used as antiviral and cytostatic drugs. In this study new uracil derivatives were tested to evaluate their cytostatic and pro-apoptotic potential. Nitrovinyl- and Bromoethynyluracil, used in cell culture on leukaemia/lymphoma cells as und colon cancer cells, showed cytotoxic and pro-apoptotic effects. It could be shown that additional substituents which increased the lipophilic character enhanced cytostatic and pro-apoptotic effects. Moreover it was proven that substances with a free thiol group have a cyto-protective effect under treatment with the new uracil derivatives. Additionally the intracellular content of glutathione as well as the changes under treatment have been evaluated.
Keywords: Cytostatic; potential; uracilderivatives
Schlagwörter: Zytostatisches; Potenzial; Uracilderivate
 
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