New Methodologies for the Regio- and Stereoselective Electrophilic Cyanation of Alkynes

by Alejandro García Barrado
Doctoral thesis
Date of Examination:2018-11-26
Date of issue:2019-01-04
Advisor:Prof. Dr. Manuel Alcarazo
Referee:Prof. Dr. Manuel Alcarazo
Referee:Prof. Dr. Dietmar Stalke
Referee:Prof. Dr. Inke Siewert
Referee:Dr. Alexander Breder
Referee:Dr. Shoubhik Das
Referee:Dr. Max Hansmann
Persistent Address: http://dx.doi.org/10.53846/goediss-7214

 

 

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Abstract

English

The ability of sulfur imidazolium thiocyanates salts to serve as a remarkable source of cyano groups was tested, thus efficiently promoting cyanations of internal and terminal alkynes. The methods described are performed under mild conditions in a metal-free environment, making these type of salts as interesting reagents for further investigations in the field.
Keywords: Electrophilic Cyanation; Imidazolium Thiocyanates; Regioselective Cyanation of Alkynes; Stereoselective Cyanation of Alkynes; Methodology; Chlorocyanation of Alkynes; Cyanative Cyclization
 
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