GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften: Recent submissions
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New redox-switches in proteins
(2024-04-26)Regulation of cellular pathways in response to the redox state of a cell is an important regulatory process. A well-established paradigm of redox-sensing is disulfide formation between two cysteine residues and cysteine ... -
Regulation of human 48S initiation complex formation
(2024-04-23)During the initiation phase of protein synthesis in humans, the small ribosome subunit interacts with initiator tRNA (tRNAi) and at least ten different initiation factors (eIFs) to form the initiation complex. The initiation ... -
Saynpatic mechanisms of noise-induced hearing loss
(2024-04-19)Noise-induced hearing loss (NIHL) is a form of acquired hearing impairment, caused by exposure to loud noise, that damages the delicate inner ear structures, possibly including the neural connections between the Inner Hair ... -
Structural and functional analyses of the HECT E3 ligase HACE1
(2024-04-19)Many crucial cellular processes rely on post-translational modifications. In particular, the covalent attachment of ubiquitin molecules, termed ubiquitylation, onto substrates, typically via lysine residues, is most commonly ... -
An investigation of cell turnover in the planarian epidermis
(2024-04-16)Cell turnover is an important biological process for maintaining tissue homeostasis. During cell turnover, newly generated cells replace unwanted cells to balance the number of cells and ensure the functionality of a tissue. ... -
Functional photoreceptors regulating light-switchable adhesion of Chlamydomonas to surfaces
(2024-04-08)The harnessing of light is one of the most remarkable evolutionary features of microalgae, allowing them to adapt and thrive in highly dynamic environments. In order to respond to environmental changes, these photoactive ... -
Mechanistic and structural characterization of human L-asparaginases
(2024-04-04)L-asparaginases are therapeutic proteins against acute lymphoblastic leukaemia (ALL), especially in children. As lymphoblastic cells depend on L-asparagine in the blood serum, its depletion by L-asparaginases leads to ... -
Structural and biochemical studies on chromatin-protein complexes in transcription initiation
(2024-04-02)Gene expression is an essential process in the cell for the development and homeostasis of any organism. The eukaryotic genome is tightly packed with nucleosomes, the basic unit of chromatin, which protects DNA integrity. ... -
Functional Analysis of Paired NLR Immune Receptors in Plant Immunity
(2024-03-21)The Arabidopsis gene AT3G04210 encodes a truncated Toll/interleukin-1 receptor nucleotide-binding leucine-rich repeat (TIR-NB-LRR or TNL) protein that is lacking the canonical C-terminal LRR domain of NLRs, and is named ... -
The contribution of oligodendrocytes to amyloid and tau pathologies in mouse models of Alzheimer’s disease
(2024-03-18)Oligodendrocytes (OLs) are the myelinating glia of the CNS and are capable of metabolically supporting long axonal projections by providing local fuel production. OL and myelin health, however, start degrading around the ... -
Investigating the Ultrastructural Consequences of Aging on Murine Inner Hair Cell Ribbon Synapses
(2024-03-05)The ribbon synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) are first synapses of the auditory pathway. They mediate the harmonized and tireless neurotransmission needed for continuous sound ... -
Amino acid metabolism in Bacillus subtilis
(2024-03-05)Amino acid metabolism is a a central field of research aiming to understand the complex reactions that take place in a cell. Amino acids are the main building blocks for proteins, and they serve as carbon or nitrogen source ... -
Mechanisms underlying age-related decline in mammalian female fertility
(2024-03-05)Reproductive longevity is crucial for fertility and impacts healthy ageing. Unlike in men, fertility in women starts to decline several decades before other signs of ageing set in. Female fertility is restricted by a limited ... -
Structural and functional studies of RNA polymerase II passage through nucleosomes
(2024-03-05)Transcription by RNA polymerase II (Pol II) is an essential process of life occurring in the context of the compact eukaryotic nucleus. While transcription elongation has been extensively studied on linear DNA in vitro, ... -
Molecular characterization of protein translocation pores
(2024-02-27)Within the intricate realm of intracellular protein transport, individual organelles are reliant upon precise and dedicated protein machineries, commonly referred to as translocon, to facilitate the translocation of proteins ... -
Identification and characterization of plant lipid droplet-associated proteins
(2024-02-23)The molecular study of plant lipid droplets, first described over a century ago, has garnered attention since the identification of oleosins in the 1980s’. In recent years, considerable progress has been achieved in ... -
Multi-nuclear magnetic resonance imaging and spectroscopy of lithium in the brain
(2024-02-23)Equipped with only three protons, lithium stands as one of the most unexpected drug discoveries in history. Despite its initial FDA approval in 1970, lithium's precise mechanism for regulating mood remains largely elusive. ... -
Functional connectivity of the L2/3 VIP-to-L4 SST cell circuit motif in the primary somatosensory and visual cortices of mouse
(2024-02-19)The mammalian cortex is comprised of a multitude of cell types, wired together in intricate circuit motifs, which are recruited during different behavioral scenarios. Broadly speaking, neocortical neurons can either be ... -
Multi-omics studies of transcription regulatory mechanisms during human cell fate transition
(2024-02-16)RNA polymerase II (Pol II) transcription is an essential process in living organisms that requires accurate regulation and coordination in order to produce protein-coding and many types of non-coding transcripts. One of ... -
The Role of the Transient Receptor Potential Vanilloid 1 (TRPV1) Channel in Sharp Wave Ripples, Place Cells, and Spatial Memory
(2024-02-09)Previous research in our lab found impaired long-term potentiation (LTP) of CA3-CA1 synapses, a fundamental process for learning and memory, in transient receptor potential vanilloid 1 (TRPV1) knockout (KO) mice. The TRPV1 ...