Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Fischer, André Prof. Dr."
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Recycling as a mechanism for extracellular matrix remodeling at the synapse
(2021-12-10)In the adult brain, the extracellular matrix (ECM) forms lattices that sheath neurons and synapses. The exceptional longevity of ECM molecules lends these lattices a unique durability, and as such, they are deemed to ... -
Role of Histone Methylation in Cognition and Effects of Different Durations of Environmental Enrichment on Learning and Memory
(2012-06-06)Part 1 Formation of stable long-term memories requires novel gene expression, and chromatin modifications have been shown to be involved in mediating the de novo gene expression which is necessary for memory formation. ... -
Role of prion protein in synucleinopathies
(2020-06-11)Synucleinopathies comprise a group of neurodegenerative diseases, characterized by deposits of aggregated alpha-synuclein (aSyn) in neurons and glia. The special hallmark is the presence of Lewy bodies and Lewy neuritis, ... -
Schizophrenia risk factor Tcf4 and gene-environment interaction in mice
(2015-02-23)Psychiatric diseases are triggered by the interaction of genetic and environmental risk factors (GxE). To model GxE in mice, we developed an approach to analysing huge behavioural data sets, which allowed us to compare ... -
Searching for molecular mechanisms of psychiatric diseases: examples from autism to rapid cycling
(2014-07-31)The thesis describes several projects exploring the molecular mechanisms of psychiatric disorders. First project studies the contribution of common variants of autism related synaptic genes to neuropsychiatric risk, as ... -
Systematic analysis of heterochromatin modification readout
(2017-06-14)Modifications of the building units of chromatin - the histone proteins and DNA - direct the functional readout of the genome and are part of the so called “epigenome” (Fischle et al., 2003b; Kouzarides, 2007). Several ... -
The 5XFAD mouse model: a tool for genetic modulation of Alzheime's disease pathology
(2012-01-25)AD mouse models contributed widely to our understanding of the pathophysiology of AD and represent invaluable tools in testing potential therapeutic interventions. In the present study, ... -
The contribution of N-terminally modified amyloid beta to the etiology of Alzheimer's disease
(2012-09-07)A heterogeneou s mixture of amyloid beta (Aβ) isoforms exists in the brains of Alzheimer's disease (AD) patients. Despite decades of research, relatively little is known about the precise contribution of these variousAβ ... -
The role of alpha-synuclein on transcriptional deregulation in Parkinson’s disease
(2018-08-31)Parkinson’s disease (PD) is a complex neurodegenerative disorder that manifests through a broad ran ge of motor and non - motor symptoms. Alpha - synuclein (aSyn) is the major ... -
The role of Kat2a during memory formation and chromatin plasticity in the aging murine hippocampus
(2013-07-18)Evolution has equipped multicellular organisms with ever more sophisticated means of processing information about the environment they live in. The hippocampus has been shown to be one of the most important structures of ... -
The Role of Lysine Acetyltransferase Tip60 in the Murine Hippocampus
(2015-07-07)Making new memories is a highly complex process, which involves rapid modifications of existing proteins, induction of gene expression, de novo protein synthesis, and the altering of neuronal structures. The cellular ... -
Therapeutic approaches for two distinct CNS pathologies
(2020-06-19)This work summarizes the analysis of two distinct therapeutic approaches for the central nervous system (CNS) pathologies, Pelizaeus-Merzbacher disease (PMD) and Glioblastoma multiforme (GBM). PMD is a severe leukodystrophy ... -
Transcriptional control of the establishment of neocortical projections in the mammalian telencephalon
(2015-01-12)Neuronal connections in the neocortex that relay and integrate informationform the basis of our higher cognitive abilities. Transcription factors play animportant role in controlling the trajectory of neuronal projections. ...