Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Rizzoli, Silvio O. Prof. Dr."
Now showing items 21-28 of 28
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Optogenetic stimulation of the cochlea
(2019-07-15)Optogenetic stimulation of the auditory nerve is a promising alternative to restore hearing. Since light can be focused on the target tissue, the optical cochlear implant (oCI) might support a major improvement in frequency ... -
Quantitative Nanoscopy of Synaptic Sites
(2023-08-23)Synapses are the basic information processing unit of the brain. Neuronal activity and memory formation thereby require a vastly dynamic and rapidly changing synaptic environment and composition. In order to function, these ... -
Regulation of vesicular trafficking in presence of mutations in contractile proteins
(2022-06-20)The molecular and cellular mechanisms underlying disease phenotypes in dilated cardiomyopathy (DCM) are diverse and to date incompletely understood. Inherited mutations in genes encoding structural components of the sarcomere ... -
Signalling from Endosomes in Neurodevelopment and Neurodegenerative Disorders
(2021-11-15)The nervous system is developed under the regulation of growth and guidance cues. This process is highly dynamic and tightly regulated by the composition, concentration and timely presence of different signalling molecules. ... -
Structure and Mechanics of Neuronal Model Systems
(2019-11-15)Neurons of advanced animals need fast and efficient mechanisms to enable the functionality of a complex nervous system. In the life cycle of synaptic vesicles this is reflected in the endocytosis which generates new vesicles, ... -
Targeting microglial CSF1R in health and disease
(2021-09-03)The main effector functions of microglia are immune, synaptic network refinement, brain insult reaction, and neurogenesis regulation. This cumulative doctoral thesis focuses on the relevance of the colony-stimulating factor ... -
The molecular anatomy of synaptic vesicle recycling at the hair cell ribbon synapse
(2019-11-19)The inner hair cell (IHC) ribbon synapse of the auditory system is a highly specialized synapse, adapted to very fast transmission rates and maintenance of synaptic vesicle release over long periods of time without showing ... -
Ultrastructural study of synaptic vesicle dynamics in murine inner hair cell ribbon synapses under sustained stimulation
(2023-07-11)Transmission of auditory information relies in the correct functioning of inner hair cell (IHC) rib-bon synapses, which mediate synaptic vesicle release in an indefatigable manner. The name-giving synaptic ribbon and the ...