Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor "Braus, Gerhard Prof. Dr."
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Interplay between α-synuclein expression and 26S proteasome chaperone Rpn14 and Rpn11 deubiquitinase in the budding yeast Saccharomyces cerevisiae
(2023-10-17)Alpha-synuclein (αSyn) in a misfolded state is the main component of Lewy bodies (LBs). These filamentous cytoplasmic inclusions are the neuropathological hallmark of Parkinson’s disease (PD). αSyn aggregates in LBs are ... -
The Aspergillus fumigatus Vap-Vip methyltransferase pathway modulates stress response, secondary metabolism and azole resistance
(2019-07-11)The VapA-VapB-VipC trimeric complex is part of an epigenetic developmental control pathway of A. nidulans. VeA-interacting protein (VipC) and VipC-associated protein B (VapB) are methyltransferases, and VapA is a zinc-finger ... -
Proteomics of Aspergillus nidulans sexually differentiated cells
(2018-10-01)The homothallic mold Aspergillus nidulans produces as overwintering structures closed sexual fruiting bodies named cleistothecia, which contain ascospores as products of meiosis. Formation of fruiting bodies is linked to ... -
AfuSomA transcriptional network in human pathogen Aspergillus fumigatus
(2015-05-19)Fungal development is regulated by environmental stimuli via various signaling pathways. For instance, the cyclic AMP dependent protein kinase A (PKA) cascade is controlling development or pathogenesis in fungi as filamentous ... -
Cross-talk between α-synuclein post-translational modifications in yeast as model of Parkinson’s disease
(2014-10-30)Post-translational modifications modulate several characteristics of proteins. They can regulate substrate activity, localization, stability, but also feature and structure, remarkably in disease-associated proteins. The ... -
Role of methyltransferases in fungal development and secondary metabolite production
(2014-02-17)Fungal development and secondary metabolism are controlled by environmental signals through regulatory proteins. VeA protein is the founding member of the velvet superfamily of fungal regulators. It is involved in light ... -
The COP9 signalosome of Aspergillus nidulans
(2009-06-04)The COP9 signalosome (CSN) is a conserved eukaryotic multiprotein complex, playing a multifaceted role in the regulation of protein degradation by the ubiquitin system. The primary function ... -
The Saccharomyces cerevisiae HtrA orthologue, Ynm3, is a chaperone-protease that aids survival under heat stress
(2008-11-13)Ynm3 is the only budding yeast protein possessing a combination of a serine protease and PDZ domains, a defining feature of the widely conserved HtrA (high temperature requirement A) protein ...