Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor "Ehrenreich, Hannelore Prof. Dr. Dr."
Now showing items 1-18 of 18
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Behavioral analyses in translational neuropsychiatric research
(2024-07-05)Cognitive impairment frequently co-occurs in a variety of neuropsychological disorders, making it an increasing burden to the affected individuals, their relatives, and society in general. Diagnostic procedures usually ... -
Computational biology and bioinformatic methods in neuropsychiatric research: From autoimmunity to cognition and erythropoietin
(2024-06-24)Research in neuropsychiatry has greatly developed in terms of complexity, both in the questions addressed and the datasets used. Advances in computational biology and bioinformatic methods have been essential to this ... -
Modeling anti-NMDAR encephalitis
(2022-07-22)The anti-NMDAR encephalitis (NMDARE) is an autoimmune condition with so far unclear etiology and pathogenesis. It manifests with a heterogeneous clinical disease course and is diagnosed based on the presence of ... -
White matter integrity of the frontal brain and its relevance for catatonia and executive function
(2021-11-22)Catatonia is a CNS derived psychomotor syndrome comprising disturbed volition and aberrant motor and behavioral features. Targeted and effective treatment today is scarce and further impeded by its heterogeneous clinical ... -
Targeting microglial CSF1R in health and disease
(2021-09-03)The main effector functions of microglia are immune, synaptic network refinement, brain insult reaction, and neurogenesis regulation. This cumulative doctoral thesis focuses on the relevance of the colony-stimulating factor ... -
Environmental and genetic correlates of neuropsychiatric diseases and the role of erythropoietin/hypoxia in the brain as potential treatment targets
(2021-06-15)Neuropsychiatric disorders are relatively frequent and present a considerable burden to affected individuals and society. Disease etiology is often complex and patients exhibit large heterogeneity regarding disease causing ... -
Effects and inducers of autoantibodies against N-methyl-D-aspartate (NMDA) receptors
(2020-03-20)Autoantibodies against the IgG class of N-methy-D-aspartate-receptor subunit GluN1 (NMDAR1-AB) were believed to cause anti-NMDAR encephalitis. However, the view was chanllenged by the finding of age-dependent seroprevalance ... -
Novel approaches to measure physiological and behavioral responses to stress
(2020-02-21)Stress is the perception of threats to one's physical or psychological integrity, leading to certain autonomous, affective, and behavioral responses. Albeit its important role in adapting to new contexts and thus increasing ... -
Erythropoietin as a driver of neurodifferentiation, neuroplasticity and cognition – A continuum view of the neuronal lineage
(2019-12-05)Erythropoietin (EPO), named after its role in hematopoiesis, has been best studied in the hematopoietic system. Studies emphasizing the expression of EPO in the central nervous system have sparked an interest in its role ... -
Genetic and autoimmune modulators of brain function in neuropsychiatric illness and health
(2018-06-15)In the present thesis, the synergetic interaction between the nervous and immune systems and the potential pathological outcomes mediated by autoimmune processes targeting the brain was addressed, with a particular focus ... -
Characterization of Ambra1 heterozygous mice as genetic mouse model of female-specific autism
(2017-09-11)Autism is known as a heritable neurodevelopmental disorder, diagnosed prior to the age of three years in humans based on three major domains: (1) impairment in social interaction (2) communication deficits (3) restricted ... -
Searching for molecular mechanisms of psychiatric diseases: examples from autism to rapid cycling
(2014-07-31)The thesis describes several projects exploring the molecular mechanisms of psychiatric disorders. First project studies the contribution of common variants of autism related synaptic genes to neuropsychiatric risk, as ... -
The EPO/EPOR system in the brain: Search for mechanisms of action
(2014-04-17)Erythropoietin (EPO) and its receptor (EPOR) are known to be essential for erythropoiesis. However, the EPO/EPOR system turned out to have additional important functions in non-hematopoietic tissue. The brain is one of the ... -
Modeling neuropsychiatric phenotypes in mice in the frame of translational neuroscience
(2014-01-20)Neuropsychiatric disorders, such as autism spectrum disorders (ASD), schizophrenia, anxiety disorders, major depression and substance use disorders are highly prevalent and contribute to disease burden worldwide. Accumulating ... -
The influence of common genetic variations in candidate genes on neuropsychiatric phenotypes
(2013-08-09)Introduction: Psychiatric disorders are ‘complex diseases’. A large proportion of the phenotypic variation of psychiatric conditions like schizophrenia and autism can be attributed to additive genetic effects (80%-90%). ... -
Phenotype-based genetic association studies in schizophrenia: Proof-of-principle for cognition-relevant genes.
(2011-05-02)Schizophrenia is the collective term for a heterogeneous group of mental disorders with a still obscure biological basis. In particular, the specific contribution of risk or candidate gene ... -
Neue Behandlungsansätze für neuropsychiatrische Erkrankungen basierend auf der Identifizierung molekularer Krankheitsdeterminanten
(2009-04-21)Major neuropsychiatric diseases, including schizophrenia and bipolar disorder, deteriorate higher brain functions leading to disorganized thinking and cognitive decline. Available treatments ... -
Signalling of hematopoietic growth factors in mammalian neural cells
(2007-07-31)This dissertation examines signalling of hematopoietic growth factors in hippocampal neurons and cortical astrocytes. The activity patterns of Akt, ERK1/2 and Stat3 after treatment with ...