Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor "Kügler, Sebastian Dr."
Now showing items 1-6 of 6
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A mifepristone-regulated adeno-associated viral vector system for regulated neurotrophic factor expression in the central nervous system.
(2013-07-03)Parkinson’s disease (PD), the second most common neurodegenerative disease in the western society, affects more than 1% of the population and its impact on the society increases with the increasing average age. Current ... -
Effects of α/β/γ-Synuclein overexpression on the mitochondria and viability of neurons, examined using genetically encoded fluorescent sensors
(2014-09-25)Parkinson’s disease (PD) is the second most common neurodegenerative disease and it affects more than 1% of the worlds population over the age of 65. A hallmark of PD is the appearance of Lewy bodies (LBs) throughout the ... -
Neurotoxicity and aggregation of β-synuclein and its P123H and V70M mutants associated with dementia with Lewy bodies
(2019-06-14)Dementia with Lewy bodies is a progressive degenerative brain disorder which accounts for 7 to 25% of all dementia cases. Two rare missense mutations of β-synuclein, P123H and V70M were identified in familial and sporadic ... -
Pathophysiological effects of Beta-Synuclein mutants P123H and V70M
(2023-07-24)Mutations in the beta-synuclein protein have been directly linked to Dementia with Lewy bodies (DLB). In particular, P123H mutation was linked to a familial case of DLB, whereas V70M mutation was identified in a sporadic ... -
Pharmacologically controlled neurotrophic factor gene therapy for Parkinson's disease
(2019-07-24)During the PhD thesis, two projects were carried out. In the first project, an inducible AAV-5 vector for expression of GDNF, under control of the approved small molecule drug mifepristone, was evaluated in rats. GDNF ... -
α-synuclein disrupts neuron network rhythmic activity when overexpressed in cultured neurons
(2021-03-09)Synucleinopathies are associated with a generalized slowing of the brain’s rhythmic activity, which co-occurs with dementia and has been connected with increased levels of α synuclein in both patients and test animals. In ...