Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor "Nave, Klaus-Armin Prof. Dr."
Now showing items 1-12 of 12
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The contribution of oligodendrocytes to amyloid and tau pathologies in mouse models of Alzheimer’s disease
(2024-03-18)Oligodendrocytes (OLs) are the myelinating glia of the CNS and are capable of metabolically supporting long axonal projections by providing local fuel production. OL and myelin health, however, start degrading around the ... -
Neurovascular coupling in a central nervous system white matter tract
(2022-08-08)Neurovascular coupling is the process by which blood vessels dilate upon increased neuronal activity. It has been extensively studied in the murine grey matter and there are several models explaining possible molecular ... -
Ageing-associated myelin dysfunction as a driver of amyloid deposition in Alzheimer’s disease
(2022-01-07)Alzheimer’s disease (AD) is the most common neurodegenerative disease with increasing prevalence due to longer lifespans in the human population. AD manifests as various age-associated cognitive impairments summarised under ... -
Unravelling the Role Cortical Myelination Plays in Higher Brain Functions
(2021-07-07)Myelination is a process within the nervous system, where axons are ensheathed by lipid-rich, multi-spiral wraps called myelin. Its main role is to expedite impulse propagation within circuitries and allow for faster ... -
Metabolism of oligodendrocytes and its involvement in axo‐glia interaction
(2019-03-12)In white matter, axonal energy homeostasis critically depends on glial support. Failure in glial-mediated delivery of metabolic substrates into the axonal compartment results in axonal energy deficit and may anticipate ... -
The role of oligodendrocytes in higher-order circuit functions
(2018-11-12)The historical conception of glial cells as the ‘glue’ that holds the brain together has dramatically changed in the last years. The glia plays an active role in several mechanisms related to information processing in the ... -
Neuronal correlates of implicit learning in the mammalian midbrain
(2016-08-29)Filtering auditory information according to its relevance is critical to elicit the appropriate behavioral response. The relevance of a sound is not carried by the sound itself but rather assigned by the brain based on ... -
Identification of a septin filament required for CNS myelin integrity
(2014-04-14)Axonal integrity and longevity require functionally intact myelin, as demonstrated by the deletion of myelin-specific genes in mice. To identify molecules that contribute to the structural organization of CNS myelin, its ... -
BACE1 dependent function of Neuregulin1 in peripheral nervous system myelination
(2010-05-26)The neuronal epidermal growth factor (EGF)-like growth factor NRG1 type III serves as a master regulator of myelination in the peripheral nervous system (PNS). It has been proposed that ... -
The Role of Phosphoinositides in the Interaction of Myelin Basic Protein with the Oligodendroglial Cell Membrane
(2010-02-09)The only protein known to be essential for myelin formation and compaction in the central nervous system is myelin basic protein (MBP). Oligodendrocytes in mutant mice that lack MBP-expression ... -
Cortical development and myelination in the absence of Schizophrenia susceptibility gene Neuregulin1
(2009-08-20)Neuregulin1 (NRG1), a gene on human chromosome 8p, encodes a family of widely expressed EGF-like growth factors that signal via ErbB receptors tyrosine kinases. The best understood function ... -
"Eine neue Rolle für Myelin-assoziierte Inhibitoren für die Mobilität von Mikroglia"
(2009-05-28)In the central nervous system of mammals, the regeneration of axons after injury is limited. The reduced ability of neurite outgrowth can be attributed, in part, to the presence of inhibitor proteins enriched in myelin. ...