Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor "Pieler, Tomas Prof. Dr."
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Characterization of the retinoic acid-induced gene network responsible for pancreas specification in Xenopus laevis
(2017-02-06)Retinoic acid (RA) is critically required for pancreas specification in Xenopus and other vertebrates. However, the gene network that is directly induced by RA-signaling in this context remains to be defined. We identified ... -
XDazl function in RNA metabolism in Xenopus laevis
(2015-11-25)Germ cell specification in Xenopus laevis depends on the inheritance of maternal determinants from the oocyte in form of mRNAs and proteins. At the onset of zygotic transcription, maternal mRNAs are subjected to miR-mediated ... -
Novel roles of Celf1 and Tia1 during vegetal RNA localization in Xenopus laevis oocytes
(2015-10-29)The localization of certain mRNAs to the vegetal cortex of Xenopus oocytes is of crucial importance for germ cell development and germ layer formation of the future embryo. Vegetal RNA localization is mediated by signal ... -
Role of cellular dynamics, adhesion and polarity in the context of primordial germ cell migration in Xenopus laevis embryos
(2014-02-11)Directional cell migration is an intensively studied process relevant for both normal development of an organism as well as for a number of pathological conditions such as chronic inflammation and cancer. Primordial germ ... -
Molecular mechanisms of germ cell specification and migration in Xenopus laevis
(2008-02-08)Vegetal localization of mRNA during Xenopus oogenesis is critical for future germ layers formation, embryonic patterning and germ line development. In frogs, a number of germ cells specific ...