Blättern GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach "Stegmüller, Judith Dr." Betreuer
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A novel role for the E3 ubiquitin ligase FBXO7 in axon-myelin interaction
(2018-06-06)The regulated turnover of proteins is an essential aspect of every cell. Cells must be able to respond to environmental changes or undergo different developmental stages, while still maintaining a balanced protein homeostasis. ... -
Functional analysis of the parkinsonism-associated protein FBXO7 (PARK15) in neurons
(2017-09-07)Parkinson's disease (PD) is a debilitating neurodegenerative disease affecting the elderly population. It has been a challenge elucidating the molecular mechanisms underlying the selective loss of dopaminergic neurons, ... -
Characterization of FBXO7 (PARK15) knockout mice modeling Parkinsonian-Pyramidal Syndrome
(2017-04-19)The second most common neurodegenerative disease, Parkinson’s disease (PD), is caused by loss of dopaminergic neurons in the substantia nigra leading to impaired motor control. Genetic analyses have revealed recessively ... -
The role of the E3 ubiquitin ligase FBXO7-SCF in early-onset Parkinson's disease
(2016-08-29)Parkinson's disease (PD) is a debilitating movement disorder. Growing evidence associates genes with familial forms of the disease. Recently, gene mutations in the FBXO7 (PARK15) gene have been identified in patients with ... -
Functional analysis of the CNS-specific F-box protein FBXO41 in cerebellar development
(2015-10-16)Neurodevelopment is a highly dynamic process governed by the tight orchestration of events such as neurogenesis, neuronal migration, morphogenesis and synaptogenesis that ultimately shape the brain. These neurodevelopmental ... -
In vitro and in vivo characterization of the E3 ubiquitin ligase RNF157 in the brain
(2015-04-20)From early neurogenesis to the maintenance of post-mitotic neurons, apoptosis plays a pivotal role. Uncontrolled apoptotic events can lead to abnormal neuronal cell loss, which is a hallmark of various neurodegenerative ... -
Characterization of the CNS-specific F-box protein FBXO41 in cerebellar development
(2014-05-28)During neurodevelopment, processes like neurogenesis, neuronal migration and morphogenesis, as well as synaptogenesis determine the shape and function of the brain. All developmental events are highly coordinated by extrinsic ... -
The role of E3 ubiquitin ligase FBXO31-SCF in neuronal morphogenesis
(2013-01-03)Neuronal development is coordinated by the interplay of extrinsic cues and intrinsic factors. These extrinsic cues act through multiple intracellular signaling pathways to regulate the cytoskeleton machinery of the ... -
The Role of RNF157 in Central Nervous System Development
(2012-11-05)Apoptosis or programmed cell death is a crucial event during neuronal development to reduce excessive neurons. In addition, neuronal apoptosis is the cause of many neurodegenerative diseases including Alzheimer’s disease ...