Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor "Wolf, Fred Prof. Dr."
Now showing items 1-19 of 19
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Feature Selectivity in Synthetic Neuronal Networks
(2024-06-06)A fundamental property of neurons in the primary visual cortex is their preference for orientation of edges. In primates and carnivores orientation selective neurons are organized into functional domains that are arranged ... -
Intercellular Coordination in Epithelial Morphogenesis
(2022-07-26)During the development of an embryo, tissue rearrangements are driven by the precisely coordinated activity of thousands of cells. How this high degree of organization is achieved and regulated is one of the most important ... -
Drift and stabilization of cortical response selectivity
(2021-08-02)Synaptic turnover and long term functional stability are two seemingly contradicting features of neuronal networks, which show varying expressions across different brain regions. Recent studies have shown, how both of these ... -
Reverse-time inference of biological dynamics
(2020-10-27)In this work I derive a mathematical theory that allows to infer directional biological dynamics in reverse time starting from their target state. I use this approach to infer an effective model of cell junction shrinkage ... -
Information Processing Analysis in Neural Networks
(2019-06-06)Populations of cortical neurons in the fluctuation-driven regime exhibit an ultrafast population response. Some theoretical studies suggest that passive, morphological features of the axon and dendrites determine the ... -
Chaotic Neural Circuit Dynamics
(2018-02-09)Information is processed in the brain by the coordinated activity of large neural circuits. Yet, we are still only starting to understand how this high-dimensional complex system gives rise to functions such as processing ... -
Oscillations in routing and chaos
(2017-10-09)The human brain is one of the most complex structures known to mankind, and arguably the most elaborate biological system that ever evolved. Studying such complex machinery whose precision and efficiency we witness in the ... -
Genetic determination and layout rules of visual cortical architecture
(2017-08-30)The functional architecture of the primary visual cortex is set up by neurons that preferentially respond to visual stimuli with contours of a specific orientation in visual space. In primates and placental carnivores, ... -
Determination of the Dynamic Gain Function of Cortical Interneurons with distinct Electrical Types
(2017-04-25)In the living brain, individual neurons are constantly bombarded by thousands of synaptic inputs, which results in a fluctuating membrane potential. Neurons under such conditions are said to operate in a “fluctuation-driven ... -
Mathematical modeling of the structure and function of inner hair cell ribbon synapses
(2017-02-03)Information about the auditory world enters the mammalian brain through ribbon synapses of inner hair cells. Due to their fundamental role in auditory processing, these nanoscopic structures have recently received a lot ... -
Cellular dynamics and stable chaos in balanced networks
(2016-01-22)A prudent approach to understanding the function of the cerebral cortex begins with understanding the repertoire of its dynamics. In this thesis, I study how interactions between single neuron properties, synaptic coupling, ... -
Reading memory traces in cultured neuronal networks by probabilistic analysis
(2014-02-21)In this thesis, I am studying the enhancement of the collective burst dynamics, burst activation and propagation in hippocampal neuronal networks in-vitro by using optogenetic techniques. Channelrhodopsin-2 transfected ... -
Modeling the origins of spatial and temporal variability in visual cortical representations
(2013-11-25)Response characteristics of orientation-tuned neurons in the visual cortex appear to be similar in mammalian lineages widely separated in evolution. The spatial arrangement of preferences across the cortex, however, shows ... -
Studies of cultured neuronal networks using light activated ion channels and pumps
(2013-02-26)In the presented thesis work, an “Optical Network Electrophysiology “ system that combines optical stimulation using optogenetic tools and multisite neuronal recording using microelectrode arrays was developed and its ... -
Optimization principles and constraints shaping visual cortical architecture
(2012-05-03)Neurons in the mammalian primary visual cortex (V1) are often preferentially driven by only one of the two eyes and respond best to oriented bar stimuli at a particular position in the visual field. Most carnivorans and ... -
Theoretical analysis of membrane properties underlying action potential phase-locking in noise-driven cells
(2011-12-09)How does the brain work? This very broad and yet, very crucial and interesting question appealed scientists from various disciplines to itself. The fact that the operation of a system of ... -
Theoretical Studies of the Dynamics of Action Potential Initiation and its Role in Neuronal Encoding
(2011-08-08)In this thesis analytically solvable neuron models are constructed to study the influence of the initiation speed and location of AP (action potential) generation on the dynamical response ... -
Chaotic Dynamics in Networks of Spiking Neurons in the Balanced State
(2011-05-30)The brain processes sensory information about the outside world in large complex networks of neurons which communicate with short electrical pulses called action potentials or spikes. The ... -
Spatio-Temporal Dynamics of Pattern Formation in the Cerebral Cortex
(2009-04-30)In this thesis I apply the tools of nonlinear dynamical systems theory to study pattern formation in the cerebral cortex on two different scales: the development of spatially complex visual ...