Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Brück, Wolfgang Prof. Dr."
Now showing items 1-11 of 11
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Multi-contrast Magnetic Resonance Imaging of Myelin and Iron in the Brain
(2022-09-27)The non-invasive characterization of brain myelin has essential applications in basic neuroscience and the clinical management of white matter brain diseases and other inflammatory and neurodegenerative diseases. Magnetic ... -
The role of Hedgehog signalling in pituitary homeostasis in vitro and in vivo
(2020-11-03)The pivotal role of the Hedgehog (Hh) signalling pathway during embryonal development of the pituitary gland is well established. However, the knowledge about its function in the adult pituitary is still sparse. Our group ... -
In vivo approach to myelin turnover and oligodendrocyte-dependent axonal integrity
(2018-10-15)Deletion of the most abundant protein of CNS myelin, proteolipid protein (PLP) causes type 2 spastic paraplegia (SPG2) in humans, which is characterized by axonal degeneration. The assumption that the primary cause of SPG2 ... -
A novel role for the E3 ubiquitin ligase FBXO7 in axon-myelin interaction
(2018-06-06)The regulated turnover of proteins is an essential aspect of every cell. Cells must be able to respond to environmental changes or undergo different developmental stages, while still maintaining a balanced protein homeostasis. ... -
AAV-based gene therapy for axonal regeneration in a rat model of rubrospinal tract lesion
(2015-04-29)Spinal cord injury (SCI) is a devastating and largely irreversible clinical condition, which can lead to permanent sensory and motor functional disabilities. Worldwide, an estimated 2.5 million people suffer from SCI and ... -
Generation and analysis of T cell receptor transgenic rats to model CNS autoimmunity
(2014-01-27)Autoreactive T cells directed against CNS antigens seem to play an essential role at least in the initiation of multiple sclerosis. To improve our understanding about the function of pathogenic T cells in CNS autoimmunity ... -
Live imaging of autoimmune responses in distinct milieus of the central nervous system
(2013-08-28)Multiple sclerosis (MS) is the most common inflammatory disease of the central nervous system (CNS). Even though it is considered to be a classical demyelinating disease, an increasing body of evidence also demonstrates ... -
Neuronal pathology in targeted cortical experimental autoimmune encephalomyelitis and multiple sclerosis
(2013-07-09)In the recent years it has become increasingly obvious that multiple sclerosis (MS) is not only a white matter (WM) disease of the central nervous system (CNS) but also involves frequently and extensively the grey matter ... -
Astroglial and therapeutic factors affect demyelination in murine models with toxic demyelination
(2013-04-16)Astrocytes might play an important role in demyelinating diseases such as multiple sclerosis (MS) since serum autoantibodies directed against the astrocytic water channel aquaporin-4 cause inflammatory demyelinating lesions ... -
Neurodegeneration in toxin-mediated demyelinating animal models of Multiple Sclerosis
(2012-11-05)Myelin is produced by a specialized membrane of oligodendrocytes in the CNS. This multilayered structure enwraps axons, providing them with trophic support and facilitates the fast transmission of electric signals. To ... -
BACE1 dependent function of Neuregulin1 in peripheral nervous system myelination
(2010-05-26)The neuronal epidermal growth factor (EGF)-like growth factor NRG1 type III serves as a master regulator of myelination in the peripheral nervous system (PNS). It has been proposed that ...