Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Brose, Nils Prof. Dr."
Now showing items 1-20 of 64
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Probing the function of Ca2+-binding C2 domains of otoferlin, a synaptic protein of sensory hair cells
(2024-11-05)The ribbon synapses in auditory inner hair cells (IHCs) are specialized to achieve indefatigable sound encoding at rates of hundreds of Hertz and with sub-millisecond temporal precision. While conventional synapses employ ... -
Investigations of Synaptic Alterations in Models of Parkinson’s Disease
(2024-07-02)Alpha-synuclein (aSyn) is a presynaptic protein implicated in physiological synaptic roles, though its precise function is largely unknown. In Parkinson's disease (PD), the initial pathological events often involve synaptic ... -
The contribution of oligodendrocytes to amyloid and tau pathologies in mouse models of Alzheimer’s disease
(2024-03-18)Oligodendrocytes (OLs) are the myelinating glia of the CNS and are capable of metabolically supporting long axonal projections by providing local fuel production. OL and myelin health, however, start degrading around the ... -
Ultrastructural study of synaptic vesicle dynamics in murine inner hair cell ribbon synapses under sustained stimulation
(2023-07-11)Transmission of auditory information relies in the correct functioning of inner hair cell (IHC) rib-bon synapses, which mediate synaptic vesicle release in an indefatigable manner. The name-giving synaptic ribbon and the ... -
Characterization of the Complexin - SNARE Protein Network in Different Synaptic Systems
(2023-01-24)At neuronal synapses, the exocytotic SNARE complex is formed by Syntaxin 1, SNAP25 and Synaptobrevin 2. Complexin (Cplx) regulates the SNARE function to achieve the high speed and spatial precision of synaptic vesicle ... -
Droplet-based giant unilamellar vesicles as a tool for pore-spanning membrane preparation and transmembrane protein reconstitution
(2022-11-22)Model membranes represent a central tool to decipher complex processes of living cells. Giant unilamellar vesicles (GUVs) are of particular interest as they are cell-like in size, observable with optical microscopy and ... -
Development of a versatile microfluidic platform to study the ionic mechanisms of vesicular neurotransmitter transporters
(2021-11-04)This thesis described the development of a novel, versatile microfluidic platform for studying the ionic mechanisms of vesicular neurotransmitter transporters in rodent synaptic vesicles (SVs). The level of filling of an ... -
Systematic comparison of the molecular mechanisms underlying the spreading of pathology in different neurodegenerative diseases
(2021-10-19)Misfolding and accumulation of disease-related proteins are common hallmarks among several neurodegenerative diseases. This phenomenon causes the progressive loss of cognitive and motor functions correlated with specific ... -
Drift and stabilization of cortical response selectivity
(2021-08-02)Synaptic turnover and long term functional stability are two seemingly contradicting features of neuronal networks, which show varying expressions across different brain regions. Recent studies have shown, how both of these ... -
Resolving Dopamine Secretion at Individual Varicosities using Carbon Nanotube-Based Optical Dopamine Nanosensors
(2021-07-23)Dopamine (DA) is a neurotransmitter that controls vital brain functions such as motor control and motivation, but little is known about the molecular mechanisms that control DA release. Neurotransmission through DA differs ... -
Molecular Mechanisms Involved In The Generation Of Inhibitory Postsynaptic Structures
(2021-07-07)In the work presented here, a set of full-length size-selected and unamplified cDNA expression libraries [30.000 CFU in total; size-fractionated into 2-3, 3-4, and 4-5 kb pools of 10.000 CFU each] was screened for proteins ... -
Unravelling the Role Cortical Myelination Plays in Higher Brain Functions
(2021-07-07)Myelination is a process within the nervous system, where axons are ensheathed by lipid-rich, multi-spiral wraps called myelin. Its main role is to expedite impulse propagation within circuitries and allow for faster ... -
Preparation and investigation of an in vitro model system for the GABAA receptor organisation machinery of inhibitory post synapses
(2020-07-22)The synaptic communication between neuronal cells is based on the release and uptake of neurotransmitters. In the mammalian brain inhibitory signal transduction relies on the neurotransmitter γ-amino butyric acid (GABA) ... -
A quantitative analysis of an average cultured neuron
(2020-04-02)Neurons are the functional unit of the brain. They have been extensively studied, from a molecular perspective up to brain wide levels. Nonetheless, we are still missing a quantitative description of the neuronal components. ... -
Characterization of distinct contrast- and luminance-sensitive pathways in the Drosophila visual system
(2020-02-03)Visual systems are capable of extracting relevant information from dynamically changing environments. This allows animals to locate objects, escape predators and collisions or estimate self-motion, among others. During the ... -
Morphological Studies of Synaptic Vesicle Recycling at the Inner Hair Cell Ribbon Synapse
(2020-01-10)Within the mammalian inner ear, sensory inner hair cells (IHCs) of the organ of Corti are required to transduce sound waves into electrical signals. Specialized synapses at the IHC basal pole, so-called ribbon synapses, ... -
Molecular mechanisms of synaptic vesicle recycling with a focus on Endophilin A and Rabconnectin-3a
(2019-11-01)Synaptic vesicle (SV) recycling at the synapse is fundamental to neurotransmission and it sustains unimpaired neuronal communication. It is a complex cell biological process, where the molecular steps are finely coordinated ... -
Mover affects a subpool of primed synaptic vesicles in the mouse calyx of Held
(2019-10-10)Neuronal communication is a complex process; synapses must be formed, neurotransmitter has to be released at precise time points and it has to be “sensed” by the receiving end of a synapse with an equal accuracy. In this ... -
A quantitative analysis of the molecular organization of dendritic spines from hippocampal neurons
(2019-08-20)Dendritic spines are the major excitatory postsynaptic compartment in the brain. Despite its essential function in synaptic transmission and plasticity, we are still lacking a comprehensive and quantitative understanding ... -
Characterization of RIS presynaptic circuits for sleep regulation in Caenorhabditis elegans
(2019-07-03)Within the field of sleep research, it is well established that all organisms, which possess a nervous system, need to sleep. This underlines the severity of sleep functions. In humans, sleep is essential for memory function, ...