Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Diederichsen, Ulf Prof. Dr."
Now showing items 1-9 of 9
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Targeting ion sensors to synaptic vesicles using a Nanobody against luminal Synaptotagmin 1
(2022-02-24)The synapse is a specialized nanostructure that connects two neurons where the ionic composition in each of its nano compartments is the driving process for synaptic transmission. Synaptic transmission relies on the ... -
Reaction mechanism of hOMPD and CaAAD at atomic resolution
(2019-12-12)Decarboxylation reactions are fundamental processes in the chemistry of the animated world. Thus, the evolution of decarboxylases brought up a stunning array of diverse enzymes utilizing a variety of different mechanisms ... -
Synthesis and Analysis of Modified SNARE Proteins with Respect to Assembly and Disassembly of the SNARE Complex
(2017-01-12)In this thesis, the first aim was to synthesise an inhibitor for the alpha-SNAP/NSF-mediated disassembly reaction of the SNARE complex. Based on identified interaction sites between alpha-SNAP and Synaptobrevin-2, suitable ... -
Investigation of Nucleosome Dynamics by Genetic Code Expansion
(2015-10-28)The DNA of eukarytic cells is compacted into a complex macromolecular structure called chromatin. Histones are the small structural proteins that form central octamers around which the DNA is wrapped to form the basic ... -
Structure and dynamics of artificial lipid membranes containing the glycosphingolipid Gb3
(2015-09-07)The lateral structure of the plasma membrane of mammalian cells is governed by the underlying actin cytoskeleton and the complex composition of the membrane. Using phase-separated membranes of the raft-like mixture ... -
Paramagnetic Tagging of Oligonucleotides for Structure Determination using NMR-Spectroscopy
(2015-03-31)Structure determination is one of the most fundamental fields of research, as it provides insights in biological systems and their mechanisms. Therein, NMR spectroscopy is an essential tool for investigations under ... -
A scanning ion conductance microscopy assay to investigate interactions between cell penetrating peptides and pore-suspending membranes
(2014-10-10)Scanning ion conductance microscopy (SICM) provides a technique for the investigation of surface topography as well as the local ion conductance of a surface without any mechanical contact between probe and sample. This ... -
Nucleosylaminosäuren als Bausteine zur Synthese modifizierter Oligonucleotide
(2014-05-13)It has been proposed that biopolymers need to be uniformly charged to form self-sustaining chemical systems. We have therefore established a method for the site-selective replacement of natural phosphodiester linkages of ... -
Catalysis at the Interface- Elucidation of the Activation Process and Coupling of Catalysis and Compartmentalization of the Peripheral Membrane Protein Pyruvate Oxidase from Escherichia coli
(2014-02-06)The thiamine- and flavin-dependent peripheral membrane protein pyruvate oxidase from E. coli (EcPOX) catalyzes the oxidative decarboxylation of the central metabolite pyruvate to CO2 and acetate with a concomitant electron ...