Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Dobbelstein, Matthias Prof. Dr."
Now showing items 1-20 of 34
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Mechanistic Characterization of CDK9 Inhibition in T-Cell Lymphoma
(2024-08-20)Mature T-cell lymphomas (mTCL) comprise a rare group of lymphoid malignancies with very diverse genetical, clinical, and pathological characteristics that are in many cases associated with poor prognosis. Current therapy ... -
Mechanisms underlying age-related decline in mammalian female fertility
(2024-03-05)Reproductive longevity is crucial for fertility and impacts healthy ageing. Unlike in men, fertility in women starts to decline several decades before other signs of ageing set in. Female fertility is restricted by a limited ... -
Multi-omics studies of transcription regulatory mechanisms during human cell fate transition
(2024-02-16)RNA polymerase II (Pol II) transcription is an essential process in living organisms that requires accurate regulation and coordination in order to produce protein-coding and many types of non-coding transcripts. One of ... -
Investigation of the role of microtubule dynamics in paracrine signaling and cell invasion in human cancer cells
(2021-09-23)Metastasis is a critical characteristic of aggressive human cancer, which is determined by the acquirement of increased cancer cell migration and invasion capabilities. Recent published work indicated that supernumerary ... -
Bioinformatics analysis of multi-omics data elucidates U2 snRNP function in transcription
(2021-08-16)Transcription by RNA polymerase II (Pol II) is an important step in cell function and regulation. Pol II transcription has been shown to be coupled to pre-mRNA splicing, but the underlying mechanisms remain poorly ... -
Gemcitabine Resistance Elicits a Calcium Dependent Epigenetic Reprogramming in Pancreatic Cancer
(2021-03-08)Pancreatic cancer is a dismal malignancy with a 5-year survival rate of 7-9%, one of the worst among all cancer types. Patients with pancreatic ductal adenocarcinoma (PDAC) usually present an advanced stage of the disease ... -
Dissecting the molecular mechanism and spatiotemporal dynamics controlling senescence entry
(2021-01-21)Senescence represents a programmed cell cycle arrest against aberrant proliferation and tumour development due to accumulated genotoxic or metabolic stress. The tumour-suppressive properties of senescence attracted the ... -
The Role of BRDT in Esophageal Squamous Cell Carcinoma
(2021-01-08)Esophageal squamous cell carcinoma (ESCC), the predominant subtype of esophageal cancer, remains a deadly malignancy due to the lack of effective therapies. Precision oncology, utilizing various techniques to identify ... -
MDM2 as a chromatin modifier
(2020-09-08)Since its discovery about 40 years ago, the transcription factor p53 has turned into the most extensively studied protein in the context of human cancers due to its essential role in promoting tumor suppression. P53 ... -
A Mitotic Actin Regulating Pathway Induces Chromosomal Instability In Human Cancer Cells
(2020-06-11)Chromosome instability (CIN) is a hallmark of human cancer and causes structural (S-CIN) as well as whole (W-CIN) chromosome aberrations. Cancers exhibiting the CIN phenotype are characterized by a large genetic heterogeneity ... -
The impact of the integrated stress response on DNA replication
(2020-05-27)The integrated stress response (ISR) is activated following various stress stimuli which leads to the phosphorylation of the translation initiation factor eIF2alpha. Phosphorylation of eIF2alpha blocks cap−dependent ... -
The Role of ARID1A in Oncogenic Transcriptional (de)Regulation in Colorectal Cancer
(2019-07-23)The deregulation of epigenetic modulation has been well established as a common occurrence in cancer. However, the extent of its involvement in the development and progression of cancer was underscored by genome- and ... -
A novel function of DPP9 in DNA damage repair via BRCA2 regulation
(2019-01-25)Eukaryotic cells are constantly exposed to exogenous and endogenous agents that induce mutational stresses in their genome, which can lead to genetic lesions, such as chromosome loss, translocations or deletions. The ... -
Role of Distal Regulatory Elements in Cancer Progression and Therapy
(2019-01-11)Enhancer elements comprise of regions of DNA that are distal to gene promoters with a characteristic capacity to affect and regulate gene transcription. Enhancers are enriched in a highly context-specific manner allowing ... -
Identification of therapeutic targets in the Burkitt’s lymphoma specific B cell antigen receptor signaling network
(2018-11-12)Burkitt’s lymphoma (BL) is an aggressive B cell neoplasm that is characterized by a chromosomal translocation, which brings the proto-oncogene c-MYC under the control of Immunoglobulin (Ig) enhancer elements leading to ... -
The membrane IgE tail imparts unique signaling properties to the B cell antigen receptor
(2017-10-23)Robust memory antibody responses are a distinguishing feature of humoral immunity and are typically marked by elevated serum immunoglobulin (Ig) titers that rapidly and effectively neutralize the invading pathogen. However, ... -
Epigenetic regulation of osteoblast differentiation
(2017-06-07)Proper temporal epigenetic regulation of gene expression is essential for cell fate determination and tissue development. However, epigenetic mechanisms involved in control of bone-specific transcriptional programs remain ... -
Epigenetic Regulation of Tumor Cell Phenotype
(2017-04-03)The Transforming Growth Factor-β (TGFβ)/SMAD signaling pathway can function as either a tumor suppressor or metastasis promoter during tumor progression. In normal epithelial cells and early stages of epithelial ... -
The Role of RNF40 mediated H2B monoubiquitination in transcription
(2017-02-13)Active gene transcription is tightly correlated with the occupancy of histone H2B monoubiquitination (H2Bub1) in the transcribed region. Therefore, it is has been commonly assumed that H2Bub1 is an exclusively positively ... -
Characterization of the retinoic acid-induced gene network responsible for pancreas specification in Xenopus laevis
(2017-02-06)Retinoic acid (RA) is critically required for pancreas specification in Xenopus and other vertebrates. However, the gene network that is directly induced by RA-signaling in this context remains to be defined. We identified ...