Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Eimer, Stefan Prof. Dr."
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Molecular and Morphological Correlates of Synaptic Vesicle Priming
(2014-10-27)Excitation-secretion coupling at nerve cell synapses is a sub-millisecond process that entails the transduction of an electrical stimulus into synaptic vesicle fusion. Before fusion, synaptic vesicles are physically docked ... -
Cellular function and toxicity of the Parkinson’s disease-related genes α-synuclein and catp-6 in C. elegans
(2013-04-09)Parkinson’s disease (PD) is the second most common neurodegenerative disease in industrialized countries. However, the molecular mechanisms leading to neuronal death in PD still remain unclear. About 5-10% of PD patients ... -
Synaptic Ultrastructure and Regulation of Synaptic Transmission in Caenorhabditis elegans
(2012-11-07)The triggered release of synaptic vesicles (SVs) is tightly regulated in time and space by an elaborate network of proteins forming the active zone (AZ). When visualized by electron microscopy (EM), a morphological hallmark ... -
Comparative studies on regulation of SNARE complex formation by the SM protein Sly1p
(2012-06-11)Sec1/ Munc18 (SM) proteins are indispensible regulators of intracellular membrane fusion. In general, the high-affinity binding partners of SM proteins are Qa-SNAREs (syntaxins). Despite the high structural homology ... -
Dense-core vesicle maturation at the Golgi-endosomal interface in Caenorhabditis elegans
(2012-06-08)Fast synaptic transmission is mediated by the triggered release of neurotransmitters from synaptic vesicles (SVs). To regulate synaptic transmission and neuronal activity, neurons also release neuropeptides and hormones ...