Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Heinrich, Ralf Prof. Dr."
Now showing items 1-20 of 38
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The Neuropharmacological Basis of Attention in Rhesus Macaques
(2025-03-07)This thesis aimed at unraveling the neuropharmacological basis of attention in rhesus macaques, focusing on the involvement of different neurotransmitter systems. Attention, as a selective filtering process, is crucial ... -
The role of RNA in synaptic physiology and neurodegeneration in synucleinopathies
(2025-01-23)Synucleinopathies are neurodegenerative disorders characterised by the pathological accumulation and aggregation of the protein alpha-synuclein (aSyn). Parkinson’s disease (PD), Dementia with Lewy bodies (DLB), multiple ... -
Development of Methods for Cardiac Tissue Characterization Using Magnetic Resonance Imaging in Animal Models
(2024-09-26)Cardiovascular diseases (CVDs) are the primary cause of death and disability globally. The progression of CVDs is often associated with functional and structural alterations, including reduced myocardial contractility, ... -
Neural circuit plasticity underlying learning and memory in Drosophila melanogaster: from synaptic connections to behavior
(2023-05-12)Understanding the principles behind olfactory higher-order associative chains formation in Drosophila is one step further into unraveling the essence of learning and memory. However, the rationale behind such mechanisms ... -
The influence of epigenetic alterations on synaptic function and memory
(2022-08-24)While memory formation is traditionally linked to changes in synaptic structure, the transcriptional processes enabling these changes are often understudied. Even though novel protein synthesis is the basis of long-term ... -
Network formation and reorganization of the olfactory system of Xenopus laevis
(2022-03-03)The olfactory system is a window to the chemical world, that permits each species to adapt to novel spaces and situations. Despite the various phylogenetic adaptations, this sensory system maintains similar functional and ... -
White matter integrity of the frontal brain and its relevance for catatonia and executive function
(2021-11-22)Catatonia is a CNS derived psychomotor syndrome comprising disturbed volition and aberrant motor and behavioral features. Targeted and effective treatment today is scarce and further impeded by its heterogeneous clinical ... -
Development of a versatile microfluidic platform to study the ionic mechanisms of vesicular neurotransmitter transporters
(2021-11-04)This thesis described the development of a novel, versatile microfluidic platform for studying the ionic mechanisms of vesicular neurotransmitter transporters in rodent synaptic vesicles (SVs). The level of filling of an ... -
Super-resolution of PSD95 remodelling during synaptic plasticity
(2021-07-01)Strengthening and weakening of synapses are a fundamental information processing unit within the neuronal circuit of the brain. It has been shown that the most abundant scaffold protein of the postsynaptic density (PSD), ... -
An omics analysis of genetic sleep loss in C. elegans
(2020-11-24)Sleep is a state of consciousness that has persisted through evolution and has become a necessity for animal welfare. In humans sleep loss has been shown to be inextricably intertwined with poor health. The prevalence ... -
Evaluation of genetic engineering and genome editing tools to develop multifactorial reproductive sterility or killing sperm systems for the improvement of the Sterile Insect Technique
(2020-11-20)Insects fulfill fundamental roles for the preservation of ecosystems such as pollination, but also represent key agricultural pests and human disease vectors accounting for immense economic losses and approximately one ... -
Therapeutic approaches for two distinct CNS pathologies
(2020-06-19)This work summarizes the analysis of two distinct therapeutic approaches for the central nervous system (CNS) pathologies, Pelizaeus-Merzbacher disease (PMD) and Glioblastoma multiforme (GBM). PMD is a severe leukodystrophy ... -
Effects and inducers of autoantibodies against N-methyl-D-aspartate (NMDA) receptors
(2020-03-20)Autoantibodies against the IgG class of N-methy-D-aspartate-receptor subunit GluN1 (NMDAR1-AB) were believed to cause anti-NMDAR encephalitis. However, the view was chanllenged by the finding of age-dependent seroprevalance ... -
Morphological Studies of Synaptic Vesicle Recycling at the Inner Hair Cell Ribbon Synapse
(2020-01-10)Within the mammalian inner ear, sensory inner hair cells (IHCs) of the organ of Corti are required to transduce sound waves into electrical signals. Specialized synapses at the IHC basal pole, so-called ribbon synapses, ... -
Erythropoietin as a driver of neurodifferentiation, neuroplasticity and cognition – A continuum view of the neuronal lineage
(2019-12-05)Erythropoietin (EPO), named after its role in hematopoiesis, has been best studied in the hematopoietic system. Studies emphasizing the expression of EPO in the central nervous system have sparked an interest in its role ... -
Evolution of central complex development: Cellular and genetic mechanisms
(2019-11-11)Brains are conserved between insect species, as they consist of a set of anatomically similar areas, or neuropils. Simultaneously, these neuropils differ in size, shape, position and developmental timing between insect ... -
Investigating post-translational modifications and novel interaction partners of otoferlin
(2019-10-30)Otoferlin is a large multi-C2-domain protein essential for hearing and fast Ca2+-triggered transmitter release from auditory IHCs. Mutations in the OTOF gene are linked to a form of autosomal recessive non-syndromic hearing ... -
Cellular stress induces RIS dependent sleep and ALA dependent sedation via EGF receptor signaling in Caenorhabditis elegans
(2019-07-15)Why do we sleep? This question is still unsolved, although sleep is such a fundamental behavioral state in all organism with a nervous system. Several physiological mechanisms, like memory consolidation, metabolic waste ... -
Ultrafast Multichannel Optogenetic Stimulation of the Auditory Pathway for Optical Cochlear Implants
(2019-01-14)In case of profound sensorineural hearing loss and deafness, cochlear implants (CIs) partially restore hearing and provide missing auditory information to the brain. Electrical stimulation of the spiral ganglion neurons ... -
The role of oligodendrocytes in higher-order circuit functions
(2018-11-12)The historical conception of glial cells as the ‘glue’ that holds the brain together has dramatically changed in the last years. The glia plays an active role in several mechanisms related to information processing in the ...