Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Jäckle, Herbert Prof. Dr."
Now showing items 1-12 of 12
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Understanding Nucleosome Assembly Regulation in Drosophila melanogaster
(2022-06-24)Nucleosomes consist of a complex of DNA and an octameric core of histone proteins, which represent the basic subunit of chromatin. The N-terminal tails of histones are target for chemical modifications, which play an ... -
Investigating phase separation mechanisms for transcriptional control
(2020-11-13)Transcription of protein-coding genes by RNA polymerase (Pol) II is a highly coordinated process. In metazoan cells, transcription is regulated both at the initiation step by recruitment of the Pol II machinery as well as ... -
Molecular Mechanisms of Germ Plasm Anchoring in the Early Zebrafish Embryo
(2020-08-14)Zebrafish germline is specified early during embryogenesis by inherited maternal RNAs and proteins called germ plasm. Only those cells containing germ plasm will become part of the germline, whereas other cells will ... -
Characterization of the retinoic acid-induced gene network responsible for pancreas specification in Xenopus laevis
(2017-02-06)Retinoic acid (RA) is critically required for pancreas specification in Xenopus and other vertebrates. However, the gene network that is directly induced by RA-signaling in this context remains to be defined. We identified ... -
Regulation of binding of HP1 associated complexes to chromatin and their role in transcription regulation in C. elegans vulva development
(2016-10-27)HP1 proteins are known to bind to H3K9me3 and thereby localize to heterochromatin. However, direct functions of HP1 in heterochromatin formation and maintenance are not clear. This is partially due to essentiality of HP1 ... -
A novel phosphatase modulating the DNA damage response and the tumor suppressor p53
(2011-09-21)The cellular genome is constantly exposed to harmful endogenous and exogenous factors. Unrepaired DNA lesions and mismatches promote genomic instability, a major cause of cancer. Therefore, ... -
Functional analysis of mitochondrial sirtuins in C. elegans and mammalian cells
(2011-09-15)Silent information regulator 2 (SIR-2) proteins, also referred to as sirtuins, are highly conserved NAD+-dependent protein deacetylases that are emerging to be important energy sensors and ... -
Identification and characterization of ADNP as a novel heterochromatin component
(2011-03-29)In eukaryotic cells genetic information in the form of long linear DNA fibers is stored in the cell nucleus. Time and tissue specific gene expression patterns are manifested by the combination ... -
Characterization of LIN-61 methyl mark binding and its function in C. elegans vulva development
(2011-03-21)In eukaryotic cells the genome is packaged into chromatin, which is composed of core histones (H2A, H2B, H3, H4), non-histone proteins and DNA. Packaging of DNA into distinct chromatin ... -
Towards Uncovering the Role of Pre-fibrillar Oligomers of á-Synuclein in the Pathogenesis of Parkinson's Disease
(2010-08-06)Parkinson s disease (PD) is a progressive neuropathological disorder that is characterized by the presence of intra-cytoplasmic inclusions called Lewy Bodies (LBs). LBs represent insoluble ... -
The role of UNC-108/RAB-2 in neuronal dense core vesicle maturation in C. elegans
(2010-05-19)Small GTPases of the Rab family are involved in vesicular transport between different intracellular compartments. C. elegans mutant alleles of unc-108/rab-2 have been isolated based on their ... -
Characterization of the Role of <i>aeneas</i> in Primordial Germ Cell Migration and Blastoderm Cellularization
(2007-09-25)The communication and mutual influence of epithelia and migratory cells is a field of high scientific and medical relevance. Many cellular processes underlying the establishment of cell ...