Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Kehlenbach, Ralph Prof. Dr."
Now showing items 1-20 of 22
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Sarcomere signaling in a patient-specific iPSC model of hypertrophic cardiomyopathy
(2025-03-07)Hypertrophic cardiomyopathy (HCM) is a severe cardiac disorder associated with ventricular hypertrophy, diastolic dysfunction, and arrhythmias, which can lead to heart failure. Inherited forms of HCM are frequently caused ... -
Investigation of the dual role of mL62 during the mitoribosome assembly and rescue
(2024-12-19)Mitochondria are eukaryotic organelles, which have their own DNA (mtDNA) that encode for 13 proteins that are essential for the oxidative phosphorylation. The mitochondrial ribosome (mitoribosome) is responsible for the ... -
Characterization of VAPA at the inner nuclear membrane: localization, membrane insertion and nuclear interactome
(2024-12-19)Tail-anchored (TA) proteins are type IV single-pass membrane proteins characterized by a long hydrophobic transmembrane domain (TMD) positioned very close to a notably short C-terminus facing the lumen. Due to their topology, ... -
Dynamics and regulation of the mitochondrial translation machinery
(2024-11-15)Throughout this project, we have successfully established and implemented a ribosome profiling protocol tailored for examination of translating mitochondrial ribosomes, thereby affording a deeper understanding of mitochondrial ... -
Investigation of the Mitochondria-ER axis and its interconnection with the MICOS complex
(2024-09-19)Mitochondria-ER contact sites (MERCS) are essential cellular hubs for the exchange of signaling molecules, lipids and metabolites. A multitude of MERCS-associated proteins have been described in mammalian cells, and rising ... -
Characterization of the stepwise maturation of the telomerase RNA TLC1 and assembly of the telomerase in Saccharomyces cerevisiae
(2021-11-04)Telomere length homeostasis is a prerequisite for cell viability. It is challenged through successive shortening, which is due to the “end-replication-problem”. This limits the cellular life span in multicellular organisms ... -
Investigation of Mitochondrial Ribosome Regulators at the Inner Membrane
(2021-09-24)Mitochondrial biogenesis relies on the proper assembly of proteins from dual genetic origin. Nuclear-encoded proteins are imported into the organelle and incorporated into multiprotein complexes together with proteins ... -
Dissecting the molecular mechanism and spatiotemporal dynamics controlling senescence entry
(2021-01-21)Senescence represents a programmed cell cycle arrest against aberrant proliferation and tumour development due to accumulated genotoxic or metabolic stress. The tumour-suppressive properties of senescence attracted the ... -
Insights into the biogenesis of the human mitochondrial ribosomal large subunit – Characterisation of mL44 and mL45
(2020-11-16)Due to the presence of high-resolution cryo-EM structures of the human mitoribosome, the understanding about the function and assembly of the intriguing mitochondrial ribonucleoprotein complex increased tremendously during ... -
Aspergillus fumigatus F-box protein Fbx15 functions are dependent on its nuclear localisation signals and are partially conserved between A. fumigatus and A. nidulans
(2020-09-08)Aspergillus fumigatus is a globally distributed opportunistic filamentous fungal pathogen mainly found in compost and represents the main cause of pulmonary aspergillosis in immunocompromised individuals. Fungal development ... -
Structure Based Search for Novel Nuclear Export Inhibiting Anti-Tumor Drugs
(2020-07-28)The intracellular distribution of proteins and ribonucleoproteins is a fundamental process in all eukaryotes that is critically vital for the normal functionality of the eukaryotic cell. In the last decades, it has been ... -
The Aspergillus fumigatus Vap-Vip methyltransferase pathway modulates stress response, secondary metabolism and azole resistance
(2019-07-11)The VapA-VapB-VipC trimeric complex is part of an epigenetic developmental control pathway of A. nidulans. VeA-interacting protein (VipC) and VipC-associated protein B (VapB) are methyltransferases, and VapA is a zinc-finger ... -
The role of mammalian TRC40 in membrane-protein targeting and chaperoning
(2019-05-24)Tail-anchored (TA) proteins are distinguished from other membrane proteins due to their particular topology. The best-characterized pathway for the targeting of TA-proteins is the GET pathway in yeast or the TRC pathway ... -
Maturation and nucleo-cytoplasmic shuttling of snRNAs in Saccharomyces cerevisiae
(2019-01-24)While nucleo-cytoplasmic shuttling of snRNAs is a well known process in higher eukaryotes, it is still unknown whether snRNAs shuttle in Saccharomyces cerevisiae. Furthermore, it is unclear why snRNA shuttling evolved in ... -
Molecular Characterization of the Mitochondrial Presequence Translocase
(2018-01-31)In this thesis, multiple pore-lining amino acid residues of the mitochondrial presequence translocation channel Tim23 were identified as constituents of the channel’s cation filter by combining single channel electrophysiology ... -
Role of WRB protein in cardiac function
(2017-08-24)The mammalian TRC40 system is a conserved pathway responsible for the post-translational targeting of tail-anchored proteins, which are characterized by a single transmembrane domain at the C-terminus and an N-terminus ... -
Characterization of mRNA export and nuclear quality control under heat stress in the yeast Saccharomyces cerevisiae
(2017-05-17)Elevated temperatures and other changes of the environment a cell lives in, can have tremendous impact on cellular processes and integrity. To counteract these threats, cells have established various mechanisms to avoid ... -
Transport of Tail-anchored Proteins to the Inner Nuclear Membrane
(2017-04-13)In contrast to the well-studied process of nucleocytoplasmic transport of soluble macromolecules, little is known about the targeting of integral membrane proteins to the inner nuclear membrane (INM), therefore the targeting ... -
Characterization of inner mitochondrial membrane architecture
(2016-08-26)The inner membrane of mitochondria is extensively folded and displays a complex architecture. Cristae junctions are highly curved tubular openings that separate the cristae membrane from the inner boundary membrane. They ... -
Atg26 is involved in selective autophagy of the major coat protein Gag of the S. cerevisiae virus L-A
(2016-01-22)Macroautophagy is a conserved catabolic pathway for the removal and recycling of cytosolic components, damaged or surplus organelles, protein aggregates or intracellular pathogens to maintain cellular homeostasis. It is ...