Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Reichardt, Holger Prof. Dr."
Now showing items 1-18 of 18
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Analysis of autoimmune lesions in grey matter
(2018-06-14)In the present thesis I demonstrated that pathogenic TβSyn cells of wild-type and receptor-transgenic origins could be reliably generated and used for inducing passive transfer EAE; active EAE could be reproducibly induced ... -
Autoimmune T cell - B cell interaction in experimental autoimmune encephalomyelitis
(2015-03-17)Although Multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are known as T cell-mediated autoimmune diseases, there is increasing evidence that B cells also play a critical role ... -
Combining gemcitabine with checkpoint kinase inhibitors to sensitize pancreatic tumors
(2015-04-15)Pancreatic tumor is one of the leading causes of cancer-related deaths in the world. Currently, the nucleoside analogue gemcitabine is the leading therapeutic drug for the treatment of pancreatic tumors. However, due to ... -
Crosstalk between the lung microenvironment and CNS autoimmunity
(2023-05-08)The contribution of the lung in shaping CNS autoimmunity is gaining relevance in the last years. Central nervous system (CNS) reactive T cells can acquire in the lung the potential to invade the CNS in experimental ... -
Evaluating the function of the Aryl Hydrocarbon Receptor in CNS autoimmunity
(2018-12-07)The aryl hydrocarbon receptor (AhR) is a ligand activated transcription factor highly expressed within the immune and nervous system. Structurally diverse endogenous and synthetic ligands activate AhR, including dietary, ... -
Molecular and cellular mechanisms of glucocorticoids in the treatment of acute graft-versus-host disease
(2012-11-19)Haematopoietic stem cell transplantation (HSCT) is often the only curative therapy for haematopoietic malignancies and some inherited diseases of the haematopoietic system. A major side effect of HSCT and a cause of morbidity ... -
Phenotypic and Functional Characterization of Natural Killer Cell Receptors in Human and Rhesus macaque
(2024-02-05)Activating killer immunoglobulin-like receptors (KIRs) cannot transmit signals directly but through signaling motifs. Since human activating KIRs lack signaling molecules, their transmembrane lysine residue pairs with ... -
Regulation of H2B Monoubiquitination Pathway in Breast cancer
(2015-01-23)H2B monoubiquitination (H2Bub1) regulation via CDK9-WAC-RNF20/40 axis has been well illustrated. It is interesting to determine the upstream regulators which dictate the process of monoubiquitination of H2B. On further ... -
Role of endogenous retrovirus promoter activity in tumor suppression
(2015-06-03)Roughly 8% of the human genome consists of human endogenous retroviruses (HERVs). They are believed to be remnants of ancient retroviral infections of the germline that were passed on from one generation to the next over ... -
Role of Histone Metabolism and Chromatin Structure in DNA Repair
(2014-06-11)During the cell cycle progression, synthesis of new histones is important to pack newly synthesized DNA and to maintain proper chromatin structure. Unlike normal mRNAs, mRNAs from replication-dependent histone genes that ... -
Role of microglia in myelin turnover
(2016-07-11)During development oligodendrocytes in the central nervous system (CNS) produce large amount of membrane to generate myelin which wraps around the axons. The synthesis, maintenance and turnover of such enormous amounts of ... -
Role of the Hedgehog receptor Patched1 in the development and function of T lymphocytes
(2013-06-18)The hedgehog signalling pathway is a highly conserved key regulator of animal development and required for homeostasis of adult tissues both in invertebrates and vertebrates. In addition, a large number of studies have ... -
The Cellular Function of USP22 and its Role in Tissue Maintenance and Tumor Formation
(2018-02-12)Colorectal cancer (CRC) is the most frequent malignancy of the gastrointestinal tract and therefore reflects a global health issue. Despite improved detection and treatment options the high mortality and morbidity rates ... -
The molecular mechanisms of myelin disassembly
(2016-08-26)Myelin is characterized by stacking of multiple layers of membrane compacted by MBP. The breakdown of myelin is a pathological hallmark of several autoimmune diseases of the nervous system. To assess the myelin fragmentation ... -
The phosphatase MKP1 as a target to enhance replicative stress and apoptosis in tumor cells
(2016-04-29)DNA replication is a tightly regulated elementary process that ensures the exact duplication and transfer of genetic information to the next generation. However, a wide range of exogenous and endogenous genotoxic insults ... -
The role and regulation of histone H2B monoubiquitination during tumorigenesis
(2014-05-23)Posttranslational histone modifications are recognized as important regulators of gene expression. One of them, the monoubiquitination of lysine 120 of histone H2B (H2Bub1), has diverse functions and is involved in gene ... -
The role of the lung in shaping CNS autoimmunity
(2019-10-24)The lung was recently identified as a central site of T cell reprogramming in experimental autoimmune encephalomyelitis (EAE), a rodent model of multiple sclerosis (MS). While residing in the pulmonary tissue, central ... -
The ubiquitin ligase G2E3 modulates cell proliferation, survival and the DNA damage response
(2014-07-28)The chemotherapeutic cisplatin is widely used to treat various tumors. By inducing crosslinking of DNA, signaling and repair pathways are activated which are referred to as the DNA damage response (DDR). However, the ...