Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Schild, Detlev Prof. Dr."
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Characterization of olfactory receptor gene expression in the olfactory epithelium of larval Xenopus laevis
(2011-02-09)Olfactory receptors comprise the largest multigene family of G protein-coupled receptors in organisms ranging from fish to primates and are the detectors of thousands of odorant molecules. ... -
Detection and functional analysis of Ca2+ microdomains and BK channels in olfactory receptor neurons of larval Xenopus laevis
(2011-09-21)Olfactory receptor neurons (ORNs) sense odors through the interaction of odorants with their receptors, accomplishing the first step of olfactory signaling via the generation of action ... -
Dinamics of Kv10.1 expression through the cell cycle of cancer and non-cancer cells
(2015-05-12)Kv10.1 is a voltage dependent potassium channel. Its expression has been reported to be widespread in clinical tumors samples of diverse origin. In contrast, expression in normal non-neural tissue has been detected at low ... -
Intracellular micromechanics of the syncytial Drosophila embryo
(2015-09-28)A developing embryo is a striking and fascinating example of self-organization and collective behavior of biological matter. In the presented work, I investigated the cytoplasmic interior of Drosophila melanogaster ... -
Investigating the Calcium Signaling at Ribbon Synapses
(2010-05-11)Using whole-cell patch-clamp and fast confocal Ca2+ imaging we show that localized Ca2+ influx sites exist at ribbon synapses in mature inner hair cells of the mouse. Spot detection ... -
Maturation of ribbon synapses in hair cells is driven by thyroid hormone
(2007-06-07)Ribbon synapses of inner hair cells (IHCs) undergo developmental maturation until after the onset of hearing. Here, we studied whether IHC synaptogenesis is regulated by thyroid hormone ... -
Modeling the origins of spatial and temporal variability in visual cortical representations
(2013-11-25)Response characteristics of orientation-tuned neurons in the visual cortex appear to be similar in mammalian lineages widely separated in evolution. The spatial arrangement of preferences across the cortex, however, shows ... -
Quantitation Strategies in Optically Sectioning Fluorescence Microscopy
(2009-06-15)The development of microscopes that can record fluorescence intensity in five and more dimensions in one experiment (e.g. space, time and colour) makes parameters available for the scientific ... -
STED nanoscopy of synaptic substructures in living mice
(2018-06-20)Optical nanoscopy has revolutionized far-field microscopy, enabling the observation of subcellular structures and dynamics from completely new perspectives. Among other fields, neuroscience benefits greatly from the ... -
Transduction in Olfactory Receptor Neurons of Xenopus laevis Larvae: Pharmacological Blockage with FM1-43 and Endocannabinoid Modulation
(2010-09-29)The sense of smell is critical for finding food and mediating emotional and social responses. A dysfunction of this sense is often associated with diseases. In the last two decades much ... -
Visualization of synaptic vesicle protein recycling during exo-endocytosis at individual hippocampal boutons
(2006-02-20)Upon exocytosis synaptic vesicle proteins are released into the plasma membrane and must be retrieved by compensatory endocytosis. When overexpressing GFP-labeled versions of the vesicle ...