Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Schlüter, Oliver Dr. Dr."
Now showing items 1-18 of 18
-
Epigenomic and transcriptomic analysis of developing, adult and aging brain: mechanisms of brain folding, neuronal function and finding novel therapy for dementia
(2021-10-13)Histone modifications and gene expression are tightly regulated processes in the brain that has been shown to play crucial role from the beginning of brain development, learning-memory formation and aging. While brain ... -
A cortical hierarchy for differential GABAergic circuit motifs as targets for stress-induced alterations in endocannabinoid signaling
(2021-09-17)Aberrant endocannabinoid (eCB) signaling has been implicated in the pathophysiology of different stress-related psychiatric diseases, such as schizophrenia, depression, and anxiety disorders. Such eCB signaling is triggered ... -
Cocaine-induced synaptic changes in the nucleus accumbens: role in drug-motivated behaviour and relapse risk
(2021-05-17)Chronic drug use creates robust and durable memories which, even after years of abstinence, can be reawakened by drug-associated cues and trigger craving and relapse. Addictive drugs elevate extracellular dopamine levels ... -
Molecular and structural correlates of ocular dominance plasticity in mice
(2020-11-11)During early postnatal life, the brain goes through critical periods of increased plasticity, which enable experience-dependent refinements of neuronal circuits. Insertion of α-amino- 3-hydroxy-5-methyl-4-isoxazolepropionic ... -
Decoding the Epigenome of Neuronal Networks in Health and Disease
(2019-05-27)Alzheimer’s disease (AD) is the most prevalent form of dementia that has vast emotional and economic implications in our society. There is no cure for this neurodegenerative disorder as the pathological changes occur years ... -
Activity-based automatic ROI generation (AARG) analysis of dendritic spine calcium transients reveals distance-dependent activity of voltage-gated calcium channels
(2018-03-20)Imaging synaptic activity in the form of calcium transients occurring in dendritic spines is advancing our understanding of nerve cell function beyond what can be achieved using electrophysiological methods alone. I have ... -
Characterization of Ambra1 heterozygous mice as genetic mouse model of female-specific autism
(2017-09-11)Autism is known as a heritable neurodevelopmental disorder, diagnosed prior to the age of three years in humans based on three major domains: (1) impairment in social interaction (2) communication deficits (3) restricted ... -
Norepinephrine induces internalization of Kv1.1 in hippocampal neurons
(2017-08-08)Norepinephrine (NE), a catecholamine produced by dopamine β-hydroxylase, is released either as a hormone from the adrenal medulla into the blood, or as a neurotransmitter in the brain. Norepinephrine signaling serves as a ... -
Determination of the Dynamic Gain Function of Cortical Interneurons with distinct Electrical Types
(2017-04-25)In the living brain, individual neurons are constantly bombarded by thousands of synaptic inputs, which results in a fluctuating membrane potential. Neurons under such conditions are said to operate in a “fluctuation-driven ... -
Cocaine-induced synaptic plasticity in the nucleus accumbens and drug-associated behavior - An unexpected dissociation
(2016-05-19)Drugs of abuse such as cocaine are known to hijack synaptic plasticity mechanisms of brain circuits underlying motivated behavior. A common mechanism of drugs of abuse is to elevate extracellular dopamine levels in the ... -
Pharmacotreatment of a mouse model of Rett syndrome with the radical scavenger Trolox: Detailed assessment of potential merits in vitro and in vivo
(2015-04-27)Rett syndrome is a severe neurodevelopmental disorder, with an incidence of ~1/1000 female births, in which most patients carry mutations in the methyl-CpG binding protein 2 gene. No cure exists so far. Rett girls are born ... -
The role of complexin I in synaptic transmission at the mouse calyx of Held synapse
(2014-08-19)Complexins are small synaptic proteins which cooperate with the SNARE-complex in synaptic transmission. Different roles of complexins in the regulation of vesicle exocytosis have been proposed. Based on the results of ... -
Molecular mechanisms of collybistin-dependent gephyrin clustering at inhibitory synapses
(2014-07-03)Information processing and transmission in neuronal networks in the mammalian brain occurs through intercellular communication between neurons at synapses. Inhibitory synapses play a key role, for example to maintain network ... -
Vision, cortical maps and neuronal plasticity in Bassoon and PSD-95 mutant mice.
(2014-03-21)Bassoon mutant mice (Bsn-/-) display a striking loss of synaptic ribbons in photoreceptor terminals, which impairs signal transduction through the retina (Altrock et al., 2003; Specht et al., 2007). Therefore we assessed ... -
Expression and function of Rab3 interacting molecules and clarin-1 in inner hair cells
(2013-09-04)Hearing depends on faithful synaptic transmission at the inner hair cell (IHC) ribbon synapse, which is orchestrated by active zone proteins. RIM (Rab3 Interacting Molecules) is one of the active zone proteins and proposed ... -
The Role of PSD-95 and Kinase Interactions in Synaptic Transmission
(2013-08-07)During development various structural and molecular changes take place in the brain leading to its maturation. These changes occur at multiple levels, including the alterations in protein expression level of single cells ... -
Characterization of neuroligin 4, a protein involved in autism spectrum disorders
(2012-11-06)Neuroligins (NLs) are ubiquitous postsynaptic adhesion proteins that are essential for synaptic maturation and function. Of the four NL isoforms expressed in the central nervous system (CNS), NL4 is of particular interest ... -
The mechanisms underlying synaptic transmission at the layer 4 of sensory cortical areas
(2011-06-08)Neurons in layer 4 (L4) of the cortex play an important role in transferring signals from thalamus to other layers of the cortex. Understanding the fundamental properties of synaptic ...