Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Schmidt, Christoph F. Prof. Dr."
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Aberration correction in STED microscopy
(2019-11-21)In the last decade, superresolution microscopy techniques became a valuable tool to study sub-cellular structures with a resolution below the diffraction limit. The use of superresolution for brain research requires to ... -
Basic coding activities of populations of Xenopus laevis olfactory receptor neurons recorded with a fast confocal line illumination microscope
(2013-09-05)The olfactory system is able to sample a large odor space with only a limited number of olfactory receptor neurons (ORN) using so-called combinatorial coding. Here, different ORN classes exhibit a broad but specific odor ... -
Forces in Cellular Growth and Division
(2016-02-05)Under confinement cell populations exert growth forces onto their surroundings. Confined cell populations can be found plentiful in nature, e.g. tumors embedded in healthy tissues, microbial populations in stone cavities ... -
High-bandwidth microrheology of cytoskeletal networks
(2012-02-08)The understanding of the material properties, the organization and the assembly of the cytoskeleton remains challenging. In this thesis the viscoelastic properties of cytoskeletal networks ... -
Intracellular micromechanics of the syncytial Drosophila embryo
(2015-09-28)A developing embryo is a striking and fascinating example of self-organization and collective behavior of biological matter. In the presented work, I investigated the cytoplasmic interior of Drosophila melanogaster ... -
Lab-on-chip design to characterize pore-spanning lipid bilayers
(2013-11-26)A powerful approach to study membrane proteins is the reconstitution in model membranes. Methods for arti cial bilayer formation are e.g. membranes on a solid support, or the classical BLM. In this project, the focus was ... -
Mechanics of suspended cells probed by dual optical traps in a confocal microscope
(2015-12-02)Cells are sensitive to mechanical cues from their environment and at the same time generate and transmit forces to their surroundings. In this thesis, we quantitatively measured forces and elastic spring constants of ... -
Molecular DNA Sensors to Measure Distribution of Cytoskeletal Forces
(2020-08-24)Actin, a major cytoskeletal biopolymer in eukaryotic cells, is crosslinked into networks of filaments and bundles. These networks are largely responsible for the maintenance of cellular shape, rigidity, and mechanical ... -
Single-molecule measurements of Kinesin motor proteins
(2014-03-13)This thesis covers the developments and new findings on different regulatory processes in Kinesin-5 motor proteins. The first two chapters give a general introduction into motor proteins and some of the well established ... -
STED nanoscopy of the living brain
(2012-05-03)Over the past decade, a new class of fluorescence microscopes has evolved which thoroughly break the diffraction limit of classical far-field light microscopy and thus provide significantly improved spatial resolution. ... -
The Level of Noise Controls the Efficiency of Natural Selection in Growing Biofilms
(2015-02-03)Many microbes live in biofilms, which are spatially structured populations. During adaptation to a new environment, beneficial mutations occur, and some of them spread through the population. Others go extinct due to ...