Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Schmidt, Manuela Dr."
Now showing items 1-8 of 8
-
Mechanisms underlying postoperative pain – A translational study
(2024-02-05)The current focus on pain following surgery is in understanding the mechanisms behind it to develop methods to reduce its impact in patients. Surgery is necessary for treating several diseases and conditions; therefore, ... -
Pathophysiological effects of Beta-Synuclein mutants P123H and V70M
(2023-07-24)Mutations in the beta-synuclein protein have been directly linked to Dementia with Lewy bodies (DLB). In particular, P123H mutation was linked to a familial case of DLB, whereas V70M mutation was identified in a sporadic ... -
Molecular physiology of sound encoding
(2021-10-26)Inner hair cells (IHC) are responsible for transforming mechanical sound-borne vibrations into electrical signals and conveying this information to the afferent spiral ganglion neurons (SGNs). Upon stimulation, the receptor ... -
Modulation of plasticity aftereffects at the sensorimotor cortex by transcranial electrical and magnetic stimulation
(2020-12-15)Non-invasive brain stimulation (NIBS) dose-dependently influences ongoing brain activity either by electrical stimulation via electrodes attached to the scalp or by magnetic stimulation via coils. The latter then induces ... -
Optogenetic stimulation of the cochlea
(2019-07-15)Optogenetic stimulation of the auditory nerve is a promising alternative to restore hearing. Since light can be focused on the target tissue, the optical cochlear implant (oCI) might support a major improvement in frequency ... -
Molecular physiology of synaptic sound encoding at the first auditory synapse
(2018-03-20)To achieve accurate encoding of sounds, inner hair cell (IHC) ribbon-type synapses are highly specialized to release synaptic vesicles (SVs) with high rates and temporal precision. A sophisticated, by far not yet fully ... -
Molecular studies of the synaptic protein otoferlin
(2017-02-24)Deafness is an interesting and intensely studied topic and can be caused by different, genetic as well as environmental, factors. One important cause of deafness are mutations in the otoferlin gene leading to non-syndromic ... -
Probing roles of TRPML in Drosophila hearing
(2016-01-15)Several transient receptor potential (TRP) channels have been implicated in Drosophila hearing, including the TRPN channel NOMPC, the TRPVs Nan and Iav, and the TRPA members Pyx and Pain. Here I report that fly hearing ...