Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Simons, Mikael Prof. Dr."
Now showing items 1-20 of 25
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Myelin pruning by microglia during development
(2019-04-26)Myelin is a lipid rich membrane produced by oligodendrocytes in the central nervous system. During development, oligodendrocyte precursor cells find their target axons and start to wrap their processes around axons, thereby ... -
Molecular Interactions between Neurons and Oligodendrocytes during Myelin Formation
(2019-04-23)Myelin is a multi-layered membrane wrapped around axons. It allows fast nerve conduction and provides the axon with trophic support. In the central nervous sys- tem (CNS), oligodendrocytes form multiple myelin sheaths. ... -
The role of oligodendrocytes in higher-order circuit functions
(2018-11-12)The historical conception of glial cells as the ‘glue’ that holds the brain together has dramatically changed in the last years. The glia plays an active role in several mechanisms related to information processing in the ... -
Development of Nanobodies to Image Synaptic Proteins in Super-Resolution Microscopy
(2018-10-17)In the recent decades, super resolution microscopy substantially contributed to the investigation of subcellular structures. A prominent example is the molecular organization of the synapse which is known to be vital for ... -
Iron Homeostasis in Neuron-Glia Interaction
(2018-03-15)One major function of glial cells is to support neurons and create an environment that allows fast signal propagation. However, when neurons are ensheathed, they also get isolated from the extracellular environment and can ... -
Epigenetic Modulation in Alzheimer's Disease: Function of Hippocampal microRNAs
(2015-12-04)MicroRNAs (miRNA) are small non-coding RNAs that play a critical role in the regulation of gene expression programs and thus key mediators of cellular homeostasis. There is increasing evidence that deregulation of miRNAs ... -
Functional analysis of the CNS-specific F-box protein FBXO41 in cerebellar development
(2015-10-16)Neurodevelopment is a highly dynamic process governed by the tight orchestration of events such as neurogenesis, neuronal migration, morphogenesis and synaptogenesis that ultimately shape the brain. These neurodevelopmental ... -
Actin turnover regulates mechanical properties of oligodendrocytes and myelin formation
(2015-10-02)The myelin sheath is a specialized membranous structure that facilitates rapid signal conduction along axonal segments. During central nervous system development, it is formed by oligodendrocytes that extend motile and ... -
Synaptic vesicles dynamics in σ1B adaptin -/- mouse model
(2015-07-20)The adaptor protein 1 (AP-1) complex of clathrin-coated vesicles (CCVs) mediates protein transport between the trans-Golgi-network and endosomes. It consists of the two large adaptins γ1 and β1, both of which bind clathrin ... -
Souffle/Spastizin regulates secretory granule maturation by sorting lysosomal cargo from immature secretory granule during zebrafish oogenesis
(2015-06-05)Successful reproduction of all sexually reproducing organisms mainly depends on the viability of the oocyte. The making of the oocyte is regulated at multiple level to ensure its quality where it carries the information ... -
A novel membrane-binding probe for the morphological and molecular characterization of synaptic vesicle recycling pathways
(2015-05-12)An important anatomical feature of neuronal synapses is the presynaptic bouton, a structure that isolates synaptic vesicle recycling from constitutive membrane trafficking pathways. However, in some neurotransmitter-releasing ... -
Dynamics and mechanics of adherent cells in the context of environmental cues
(2015-03-25)Cellular behavior is influenced by many biochemical but also physical factors in the direct cellular environment. Thereby, cells not only react to external cues, the interaction between cells and their environment is also ... -
Autoimmune T cell - B cell interaction in experimental autoimmune encephalomyelitis
(2015-03-17)Although Multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are known as T cell-mediated autoimmune diseases, there is increasing evidence that B cells also play a critical role ... -
The influence of common infections on clinical course and neurodegeneration in an animal model of multiple sclerosis
(2015-03-05)The course of Multiple Sclerosis (MS), a chronic autoimmune disease, can be influenced by systemic infections. The common notion is that bacterial infections worsen disease symptoms and lead to enhanced neurodegeneration. ... -
Rab26 mediates selective targeting of synaptic vesicles to the autophagy pathway
(2015-02-26)In recent years it has been shown that macroautophagy regulates the turnover of postsynaptic receptors and modulates presynaptic neurotransmission. However it is still unclear whether the presynaptic protein turnover is ... -
Schizophrenia risk factor Tcf4 and gene-environment interaction in mice
(2015-02-23)Psychiatric diseases are triggered by the interaction of genetic and environmental risk factors (GxE). To model GxE in mice, we developed an approach to analysing huge behavioural data sets, which allowed us to compare ... -
Studying Protein Organization in Cellular Membranes by High-Resolution Microscopy
(2014-10-09)Most membrane proteins are found in clusters in the plasma membrane. For abundant proteins it is apparent that the clusters also tend to have patterned distributions, rather than being randomly scattered. To reveal the ... -
Neuronal pathology in targeted cortical experimental autoimmune encephalomyelitis and multiple sclerosis
(2013-07-09)In the recent years it has become increasingly obvious that multiple sclerosis (MS) is not only a white matter (WM) disease of the central nervous system (CNS) but also involves frequently and extensively the grey matter ... -
Pathophysiological Characterization of intra‐ and extracellularly aggregated Amyloid Peptides in Dementias
(2013-06-28)Alzheimer’s Disease (AD) is the most common form of dementia in the elderly population and is neuropathologically characterized by hippocampal neurofibrillary degeneration, chronic inflammation as well as widespread ... -
Astroglial and therapeutic factors affect demyelination in murine models with toxic demyelination
(2013-04-16)Astrocytes might play an important role in demyelinating diseases such as multiple sclerosis (MS) since serum autoantibodies directed against the astrocytic water channel aquaporin-4 cause inflammatory demyelinating lesions ...