Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Stülke, Jörg Prof. Dr."
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Amino acid metabolism in Bacillus subtilis
(2024-03-05)Amino acid metabolism is a a central field of research aiming to understand the complex reactions that take place in a cell. Amino acids are the main building blocks for proteins, and they serve as carbon or nitrogen source ... -
Comparative systems biological analysis of the potential of a high-performance expression platform – Bacillus pumilus
(2023-06-29)This project was supported by the German Federal Ministry of Education and Research (BMBF) with the grant ID: Fkz.031B057 under the Industrial Biotechnology Innovation Initiative. The particular program corresponds to the ... -
Validation of novel protein-protein interactions in Bacillus subtilis
(2023-01-12)Protein-protein interactions are the basis for many biological processes in the cell. Understanding these interactions is crucial for the general analysis of how the cell functions and the potential identification of ... -
Structural and functional characterisation of tRNA modifying enzymes
(2021-09-10)Posttranscriptional and posttranslational modifications are key regulatory mechanisms to expand biological properties of proteins and nucleic acids in living cells. A tremendous number of chemical modifications is found ... -
Vitamin B6 metabolism and underground metabolic routes in the Gram-positive bacterium Bacillus subtilis
(2021-07-16)Genome-reduced bacteria give the opportunity to study essential gene functions but also give the starting point for biotechnological production pathways. The MiniBacillus project aims to produce a genome reduced Bacillus ... -
Identification and Characterisation of Lipid Droplet-Localised Proteins
(2021-03-16)Lipid droplets (LD) are unique organelles, whose physiological relevance has been underestimated for a long time. Well-known in seed tissues for storing triacylglycerol (TAG) to fuel post-germinative seedling establishment, ... -
Molecular insights into the roles of RNA helicases during large ribosomal subunit assembly
(2021-02-25)RNA helicases are enzymes present in all domains of life that are important in many aspects of RNA metabolism. They harbor a conserved helicase core that uses the energy of NTP binding and hydrolysis to change affinity to ... -
Clostridioides difficile: Analysis on Single Cell Motility and on Antibiotic Resistance
(2020-12-22)Clostridioides difficile, formerly in the genus Clostridium, is a Gram positive obligatory anaerobic spore forming bacterium. C. difficile is the leading nosocomial gastrointestinal pathogen in the western world. In ... -
Manipulating co-regulators of RUNX2 and SOX9 to enhance the chondrogenic potential of chondrogenic progenitor cells in osteoarthritis
(2020-12-11)Osteoarthritis (OA) is a degenerative disease of the joint leading to the degradation of the articular cartilage. Current therapies cannot halt or reverse the disease, leading to a severe impact on life quality accompanied ... -
A possible functional link between RNA degradation and transcription in Bacillus subtilis
(2020-09-24)Cellular levels of RNA depend on the rate of its synthesis and degradation. While synthesis is performed by RNA polymerase conserved in all domains of life, the enzymes responsible for RNA degradation are more unique ... -
Functional analyses of RNA helicases in human ribosome biogenesis
(2019-10-30)Eukaryotic ribosomes are essential ribonucleoprotein (RNP) complexes consisting of four ribosomal RNAs (18S, 5S, 5.8S, 28S/25S) and approximately 80 ribosomal proteins, which are required for the process of translating the ... -
A protein in search of a function: The c-di-AMP-binding protein DarA of Bacillus subtilis
(2019-07-26)Adaptation to changing environmental conditions is crucial for any organism to thrive in nature. Bacteria like the Gram-positive model organism Bacillus subtilis have evolved so-called second messengers to facilitate ... -
Identification of essential and virulence genes in Mycoplasma pneumoniae
(2019-04-16)The bacterial group of Firmicutes includes many pathogenic bacteria, as Mycoplasma pneumoniae. The Gram-positive, but cel wall-less bacterium is characterized by a minimal genome with only 694 genes. Elucidating the function ... -
Cyclic di-AMP homeostasis and osmoregulation in Listeria monocytogenes
(2019-04-05)The second messenger cyclic diadenosine monophosphate (c-di-AMP) is essential for most of the bacteria synthesizing the nucleotide. c-di-AMP is produced by diadenylate cyclases (DACs) and degraded by specific phosphodiesterases ... -
MiniBacillus - the construction of a minimal organism
(2019-04-04)The MiniBacillus project is a minimal genome project. It attempts to reduce the genome of the model organism Bacillus subtilis in a top-down approach by deleting not necessary parts of the genome step by step. In this work, ... -
Maturation and nucleo-cytoplasmic shuttling of snRNAs in Saccharomyces cerevisiae
(2019-01-24)While nucleo-cytoplasmic shuttling of snRNAs is a well known process in higher eukaryotes, it is still unknown whether snRNAs shuttle in Saccharomyces cerevisiae. Furthermore, it is unclear why snRNA shuttling evolved in ... -
Insights into the biofilm formation of Bacillus subtilis
(2018-10-01)Bacillus subtilis forms highly structured biofilms to protect itself against harmful environments, and to have an advantage in the competition with other species. The cells of B. subtilis that secrete the biofilm matrix, ... -
Functional characterisation of RNA helicases in the remodelling of pre-ribosomal subunits
(2018-07-13)DEAD/H-box RNA helicases are ubiquitously expressed enzymes, which are characterised by a conserved helicase core of two RecA-like domains containing sequence motifs required for substrate binding and hydrolysis of NTP. ... -
Interactions and functions of RNA-binding proteins
(2018-04-13)Alongside several well-known modifications in DNA and proteins, more than 100 different types of chemical modification are also found in cellular RNAs. RNA modifications can influence the secondary structure and interactions ... -
SubtiWiki 3.0: A relational database for the functional genome annotation of the model organism Bacillus subtilis
(2018-02-12)Biological databases emerged in the 1970s along with the rapid development of information science. Since then, they have greatly helped the research community in data management and information sharing, especially the model ...