Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Stegmüller, Judith Dr."
Now showing items 1-16 of 16
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A novel role for the E3 ubiquitin ligase FBXO7 in axon-myelin interaction
(2018-06-06)The regulated turnover of proteins is an essential aspect of every cell. Cells must be able to respond to environmental changes or undergo different developmental stages, while still maintaining a balanced protein homeostasis. ... -
Dlk1 Membrane-to-Nuclear Signalling During Motor Neuron Functional Diversification
(2017-11-20)Motor neurons of the spinal cord and hindbrain are responsible for translating neural commands into movements. For the execution of smooth movements, it is necessary that motor neuronal impulses are in turn translated into ... -
Roles of the Nedd4 Family E3 Ligases in Glial Function and Nerve Cell Development
(2017-05-09)Protein ubiquitination is one of the core regulatory post-translational modification in neuronal development. In this study, we used brain specific KO mice to identify novel substrate proteins of several Nedd4 family E3 ... -
Plasticity-dependent modulation of mitochondrial biogenesis determining motor neuron function and vulnerability
(2016-10-10)Axon terminals are likely the compartments of highest energy demand in the particularly active and polarized cells that are motor neurons. Paradoxically, although the particularly high-energy demand of motor neurons could ... -
The role of the E3 ubiquitin ligase FBXO7-SCF in early-onset Parkinson's disease
(2016-08-29)Parkinson's disease (PD) is a debilitating movement disorder. Growing evidence associates genes with familial forms of the disease. Recently, gene mutations in the FBXO7 (PARK15) gene have been identified in patients with ... -
Functional analysis of the CNS-specific F-box protein FBXO41 in cerebellar development
(2015-10-16)Neurodevelopment is a highly dynamic process governed by the tight orchestration of events such as neurogenesis, neuronal migration, morphogenesis and synaptogenesis that ultimately shape the brain. These neurodevelopmental ... -
Roles of the HECT-Type Ubiquitin E3 Ligases of the Nedd4 and WWP Subfamilies in Neuronal Development
(2015-05-21)Protein ubiquitination is a core regulatory principle in neuronal development. In this study, I used brain specific KO mice to investigate the roles of several HECT-type Nedd4 superfamily E3 ligases, i.e. Nedd4-1, Nedd4-2, ... -
In vitro and in vivo characterization of the E3 ubiquitin ligase RNF157 in the brain
(2015-04-20)From early neurogenesis to the maintenance of post-mitotic neurons, apoptosis plays a pivotal role. Uncontrolled apoptotic events can lead to abnormal neuronal cell loss, which is a hallmark of various neurodegenerative ... -
Transcriptional control of the establishment of neocortical projections in the mammalian telencephalon
(2015-01-12)Neuronal connections in the neocortex that relay and integrate informationform the basis of our higher cognitive abilities. Transcription factors play animportant role in controlling the trajectory of neuronal projections. ... -
Molecular Control of Pyramidal Neuron Fate Determination in the Developing Neocortex
(2015-01-12)The pyramidal neurons of the neocortex, which form the neural substrate for our higher cognitive abilities, arise from a single layer of neuroepithelium lining the dorsal ventricles. It has been of immense interest to study ... -
Coding and Non-Coding RNA in Age-Associated Memory Impairment and Alzheimer's Disease
(2014-06-03)The phenomenon of population aging, caused by increased life expectancy and declining birth rates, has resulted in a high, and continuously rising proportion of elderly people in the population. This means it is critical ... -
Characterization of the CNS-specific F-box protein FBXO41 in cerebellar development
(2014-05-28)During neurodevelopment, processes like neurogenesis, neuronal migration and morphogenesis, as well as synaptogenesis determine the shape and function of the brain. All developmental events are highly coordinated by extrinsic ... -
Identification of a septin filament required for CNS myelin integrity
(2014-04-14)Axonal integrity and longevity require functionally intact myelin, as demonstrated by the deletion of myelin-specific genes in mice. To identify molecules that contribute to the structural organization of CNS myelin, its ... -
The role of E3 ubiquitin ligase FBXO31-SCF in neuronal morphogenesis
(2013-01-03)Neuronal development is coordinated by the interplay of extrinsic cues and intrinsic factors. These extrinsic cues act through multiple intracellular signaling pathways to regulate the cytoskeleton machinery of the ... -
Assessment of Epigenetic profile in Alzheimer's disease
(2012-11-30)Alzheimer's disease is caused by multivariate factors with a convergent insult to neuronal integrity leading to cognitive decline and neurodegeneration. To develop an efficient therapeutic strategy for treatment of AD calls ... -
The Role of RNF157 in Central Nervous System Development
(2012-11-05)Apoptosis or programmed cell death is a crucial event during neuronal development to reduce excessive neurons. In addition, neuronal apoptosis is the cause of many neurodegenerative diseases including Alzheimer’s disease ...