Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Wahl, Markus Prof. Dr."
Now showing items 1-8 of 8
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Structural and functional studies of the spliceosomal RNP remodeling enzyme Brr2
(2013-06-25)The spliceosome is a highly dynamic, multi-MDa eukaryotic RNA-protein (RNP) machinery that catalyzes precursor messenger RNA (pre-mRNA) splicing. Pre-mRNA splicing entails the excision of non-coding introns and the joining ... -
Sec1p/Munc18 (SM) proteins and their role in regulating secretion in Saccharomyces cerevisiae and Caenorhabditis elegans a comparative approach
(2013-01-04)The members of the Sec1p/Munc18 (SM) family of proteins are indispensible regulatory elements that act at the post-docking step prior to fusion; they exert their function mainly through their interaction to the Qa-SNAREs ... -
Comparative studies on regulation of SNARE complex formation by the SM protein Sly1p
(2012-06-11)Sec1/ Munc18 (SM) proteins are indispensible regulators of intracellular membrane fusion. In general, the high-affinity binding partners of SM proteins are Qa-SNAREs (syntaxins). Despite the high structural homology ... -
Reconstituted SNARE-mediated fusion: towards a mechanistic understanding
(2012-03-20)A novel and well-characterized model system has been developed and used in order to extract mechanistic insights on the SNARE-mediated fusion process. The reconstitution of SNAREs onto large ... -
Kristallographische Untersuchungen zur Schweren Kette von Dynein und dem Capping-Protein Cap32/34
(2012-03-16)Intracellular movements are an essential prerequisite for material transport, cell division and food ingestion. They can be mediated through two different ways. Firstly, through motor ... -
Self-association of adenovirus 5 E1B-55 kDa as well as p53 is essential for their mutual interaction
(2009-12-15)P53 is at the center of the control systems that mediate the response to DNA damage, leading to cell cycle arrest or apoptosis. Virus infection can cause a DNA damage response through virus ... -
New Algorithms for Macromolecular Structure Determination
(2009-10-28)Detailed three dimensional information of macromolecules is often crucial to the study of biological systems. Structural data have for example been used to elucidate the basis of diseases ... -
The role of protein phosphorylation in regulation of carbon catabolite repression in Bacillus subtilis
(2008-11-20)CCR is one of the most thoroughly investigated signal transduction system in bacteria. It allows the bacteria to adapt to changes in the availability and supply of different carbon sources. ...