Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Wienands, Jürgen Prof. Dr."
Now showing items 1-20 of 27
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Phase Separation Studied by Nuclear Magnetic Resonance
(2024-01-04)Signal transduction by the ligated B cell receptor (BCR) depends on the pre-organization of its intracellular components, such as the effector proteins SLP65 and CIN85 within phase-separated condensates. These liquid-like ... -
Crosstalk between the lung microenvironment and CNS autoimmunity
(2023-05-08)The contribution of the lung in shaping CNS autoimmunity is gaining relevance in the last years. Central nervous system (CNS) reactive T cells can acquire in the lung the potential to invade the CNS in experimental ... -
Modeling anti-NMDAR encephalitis
(2022-07-22)The anti-NMDAR encephalitis (NMDARE) is an autoimmune condition with so far unclear etiology and pathogenesis. It manifests with a heterogeneous clinical disease course and is diagnosed based on the presence of ... -
NFATc1 driven ER-stress responses in the progression of non-alcoholic fatty liver disease
(2021-06-30)Non-alcoholic fatty liver disease (NAFLD) mirrors the hepatic manifestation of the metabolic syndrome and is defined by progressive fat accumulation in hepatocytes (steatosis). Uncomplicated NAFLD may progress to a severe ... -
Nucleoporin-binding nanobodies that either track or trap uclear pore complex assembly
(2021-03-25)Nuclear pore complexes (NPCs) are large multi-protein assemblies that control the transport of macromolecules between the nucleus and the cytoplasm. Their formation from ~ 1,000 individual polypeptides is an impressive ... -
Role of antibodies in autoimmunity of the central nervous system
(2020-07-09)Although T cells are the main players in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE), the role of B cells and their soluble effector molecules (antibodies) is being progressively ... -
Unraveling details of CIN85/CD2AP assistance to SLP65-mediated B cell activation
(2020-06-18)The hallmark of adaptive immunity is the production of specific antibodies. This process is initiated upon the ligation of the B cell antigen receptor (BCR) which activates multiple intracellular signaling cascades through ... -
Effects and inducers of autoantibodies against N-methyl-D-aspartate (NMDA) receptors
(2020-03-20)Autoantibodies against the IgG class of N-methy-D-aspartate-receptor subunit GluN1 (NMDAR1-AB) were believed to cause anti-NMDAR encephalitis. However, the view was chanllenged by the finding of age-dependent seroprevalance ... -
Elucidating the mechanisms of disease-triggering myelin-specific autoantibodies
(2019-10-24)Although T cells are commonly known to be the driving force of disease pathogenesis in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE), B cells and their soluble effector molecules ... -
Identification of therapeutic targets in the Burkitt’s lymphoma specific B cell antigen receptor signaling network
(2018-11-12)Burkitt’s lymphoma (BL) is an aggressive B cell neoplasm that is characterized by a chromosomal translocation, which brings the proto-oncogene c-MYC under the control of Immunoglobulin (Ig) enhancer elements leading to ... -
Nanobodies as new tools for studying large cargo transport and lamina organization
(2018-06-26)Nanobodies are the smallest recombinantly expressed antibody fragments, which show outstanding performance in numerous applications. In this work, we set out to generate nanobodies as tools to study nucleo-cytoplasmic ... -
Genetic and autoimmune modulators of brain function in neuropsychiatric illness and health
(2018-06-15)In the present thesis, the synergetic interaction between the nervous and immune systems and the potential pathological outcomes mediated by autoimmune processes targeting the brain was addressed, with a particular focus ... -
The membrane IgE tail imparts unique signaling properties to the B cell antigen receptor
(2017-10-23)Robust memory antibody responses are a distinguishing feature of humoral immunity and are typically marked by elevated serum immunoglobulin (Ig) titers that rapidly and effectively neutralize the invading pathogen. However, ... -
Biochemical characterization of presynaptic membrane protein complexes
(2017-09-13)At chemical synapses, synaptic vesicles, membrane-enclosed entities filled with neurotransmitters, undergo exocytosis at restricted areas of the presynaptic membrane called active zones (AZ). The core AZ proteins form a ... -
Vav guanine nucleotide exchange factors control B cell antigen receptor-induced Ca2+-signaling
(2016-03-15)Differentiation of B cells into antibody secreting plasma cells is an indispensable step to cope with pathogens. Antigen binding to the B cell antigen receptor (BCR) initiates signaling cascades leading in combination with ... -
Structural and functional elucidation of the primary transducer module of the B cell antigen receptor
(2015-07-27)Interaction of an antigen with the B cell antigen receptor (BCR) initiates signaling cascades leading to B cell activation, proliferation and differentiation. Signal transduction downstream of the BCR depends on the adaptor ... -
Multimolecular adaptor protein complexes in B cell receptor signaling
(2015-07-03)The activation of B cells is the crucial step of the humoral immune response. This process is controlled by the B cell receptor (BCR) signaling pathway which is initiated by antigen recognition. An elaborated and detailed ... -
Autoimmune T cell - B cell interaction in experimental autoimmune encephalomyelitis
(2015-03-17)Although Multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are known as T cell-mediated autoimmune diseases, there is increasing evidence that B cells also play a critical role ... -
Analysis of genetic interactions and hierarchies of Wnt-signaling components in vivo
(2013-02-13)In cooperation with other signaling cascades the Wnt/β-catenin signaling pathway is an essential regulator of embryonic development as well as adult tissue homeostasis and stem cell proliferation. Mutations in components ... -
Das synaptische Vesikelrecycling: Molekulare Funktionen des AP-1-Komplexes und seiner σ1B-Adaptinuntereinheit
(2012-09-26)The heterotetrameric AP-1-complex is localized to trans-Golgi-Network (TGN) and early endosomes. It mediates specific clathrin-dependant vesicular pathways. In vertebrates three isoforms of its σ1 subunit are expressed: ...