Schlafbeschwerden bei Depressionen und Bipolarer Störung im Therapieverlauf unter intermittierender Theta-Burst-Stimulation oder medikamentöser Behandlung
Sleep complaints in depression and bipolar disorder course of therapy under intermittent theta burst stimulation or drug treatment
von Valérie Aurelia Lucie Zimmeck
Datum der mündl. Prüfung:2024-01-17
Erschienen:2024-01-17
Betreuer:PD Dr. Roberto Goya-Maldonado
Gutachter:Prof. Dr. Jens Wiltfang
Gutachter:Prof. Dr. Eric Leibing
Dateien
Name:Zimmeck_Valérie_Dissertation - für eDiss.pdf
Size:1.31Mb
Format:PDF
Zusammenfassung
Englisch
A total of 73 test subjects in a depressive phase were compared over 5 weeks for changes in their sleep complaints over the course of different therapies: 38 subjects received intermittent theta burst stimulation and 35 subjects received conventional antidepressants. A generalised linear model was used for the analysis. The study groups did not differ statistically significantly in age, gender and total years of education. The sleep complaints measured by the sleep items of the HDRS and sleep duration improved statistically significantly over time, but no statistically significant difference was observed between the treatment groups. Subjects with high initial insomnia experienced experienced a statistically significant improvement in both treatment groups. The improvement of sleep complaints correlated statistically significantly with a general response to treatment and an improvement in anxiety symptoms. No difference was found between the standardised and personalised stimulation protocol on sleep complaints. These results indicate an equivalence of magnetic stimulation compared to antidepressants to alleviate sleep complaints in depression. One advantage of magnetic stimulation is that it has fewer side effects. Further studies with polysomnography are necessary to demonstrate the effectiveness of intermittent theta burst stimulation.
Keywords: MDD