Browsing Human- und Zahnmedizin by Advisor & Referee "Bayer, Thomas A. Prof. Dr."
Now showing items 1-20 of 27
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Der Einfluss von Aβ4-42 auf die Kognition und die Anwendung von Suchstrategien im Morris Water Maze im Tg4-42-Mausmodell
(2024-03-25)The relevance of Alzheimer's dementia for our society is increasing. Soluble amyloid beta (Aβ) plays a particularly important role in the genesis of this disease. Aβ4-42 in particular, which is truncated before the fourth ... -
Passive Immunisierung mit dem monoklonalen Antikörper NT4X am Tg4-42-Mausmodell für die sporadische Form der Alzheimer Erkrankung
(2023-01-27)Alzheimer´s dementia is a chronic-progressive neurodegenerative disease that can lead to extensive impairments in the daily life of affected patients due to pronounced cognitive impairments. Significant neuropathological ... -
The role of Neuroligin-2 in fear circuits
(2023-01-02)In the past decades, strong evidence arose that the emergence of a large variety of neuropsychiatric conditions is caused by perturbations of the synaptic transmission on the molecular level. The synapse is the key structure ... -
Modulation der synaptischen Plastizität im Rett-Syndrom durch Antioxidantien-Fütterung
(2021-10-05)Rett syndrome is a severe neurodevelopmental disorder that almost exclusively affects females. Upon an apparently normal development during the first 6 – 18 months of life, developmental stagnation and especially neurological ... -
Auswirkung der TLR4-Inhibition bei verschiedenen Applikationswegen im Modell des ischämischen Schlaganfalls
(2020-11-10)Stroke is one of the most common diseases today and one of the leading causes for physical and psychological disability. Except of the recanalisation therapies that have been established there are no other therapeutical ... -
Studie zur Rolle N-trunkierter Amyloid-β-Peptide bei der Alzheimer-Krankheit
(2019-10-15)Alzheimer’s disease (AD) is a neurodegenerative progressive disease, characterized by extracellular amyloid accumulation, neurofibrillary tangles and neuron loss. N-terminally truncated Aβ4-42 and pyrog ... -
Passive Immunisierung mit einem N-trunkierten Abetaspezifischen Antikörper - Therapeutisches Potential von NT4X in einem familiären Alzheimer-Mausmodell
(2019-03-25)Abstract Alzheimer’s disease is a progressive neurodegenerative illness whose patients suffer from memory loss, problems managing everyday life and increasing helplessness. Worldwide there is a prevalence of over 47 ... -
Beurteilung des therapeutischen Potenzials von intraperitoneal injiziertem Metallothionein-II im ischämischen Schlaganfallmodell an der Maus
(2019-02-25)All across the globe ischemic strokes are one of the prime contributors to death as well as physical and psychological disability. Even though prospects for therapeutic treatment during the acute phase have experienced ... -
Therapiemöglichkeiten der Alzheimer-Krankheit durch passive Immunisierung mit dem NT4X-Antikörper im Tg4-42hom-Mausmodell
(2017-07-05)Aβ4-42 is one of the major variants of beta-amyloid (Aβ) in the Alzheimer brain and one of the earliest to appear in the development of the disease. It shows an increased aggregation tendency and toxicity. Furthermore it ... -
Neuropathological and behavioral alterations in two transgenic mouse models of Alzheimer´s disease
(2016-07-05)According to the influential amyloid cascade hypothesis cerebral accumulation of Aβ is the key event in the pathogenesis of Alzheimer´s disease. Aβ deposits occur as soluble forms, as well as insoluble forms. It is assumed ... -
Therapeutisches Potenzial und Langzeiteffekt der TLR4-Inhibition bei der fokalen zerebralen Ischämie
(2016-04-11)Ischemic stroke is known to be one of the leading causes of death worldwide. As therapeutic options especially for treatment beyond 4,5 to 6 hours after the beginning of symptoms are limited, recent studies have focussed ... -
Untersuchungen über die Auswirkungen von Geschlecht und genetischem Hintergrund auf die Alzheimerpathologie im 5xFAD-Mausmodell
(2015-06-10)Alzheimer's disease (AD) is the most prevalent cause of dementia in the industrial nations. It leads to a constant decline of cognitive capabilities to the point of entire need of care. Since every fifth person over 90 ... -
Die Rolle der Beta-Sekretase bei der Myelinisierung im Zentralen Nervensystem
(2014-04-15)BACE1, the beta-secretase, plays a significant role in the formation of amyloid, a histopathological hallmark of Alzheimer's Disease. The physiological function of BACE1 remains unclear. Recent studies showed a role in ... -
Untersuchung der Wirkung von HDAC-Inhibitoren auf das Amyloid-Vorläufer-Protein (APP) in Tumorzellen
(2013-09-18)The ß-amyloid precursor protein (APP) is an integral membrane protein, which is expressed in neuronal and non-neuronal human cells. In addition to its well-known relevance in the pathogenesis of Alzheimer’s disease, APP ... -
Localization of the voltage-gated Kv10.2 potassium channel in the mouse organism
(2013-09-10)Already 100 years ago, the importance of ion channels for nerve cell conduction was described. Subsequently, an expression und function of ion channels outside of the nervous system was discovered. Approximately 20 years ... -
Einfluss einer intrazerebralen Infektion mit Escherichia coli auf den Verlauf der Alzheimer-Demenz im Mausmodell
(2013-06-24)Bacterial infections often worsen the existing neurological symptoms of patients with neurodegenerative diseases such as Alzheimer´s disease. Not only the acute consequences in the sense of a delirium but also the long-term ... -
Role of amyloid beta protein modulation in Alzheimer's disease
(2012-07-17)Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly. It is mainly characterized by the deposition of amyloid plaques and neurofibrillary tangles. In addition, inflammatory processes in ... -
Die Bedeutung des Pyroglutamat-Abeta-Oligomer-Blutplasmaspiegels und des Apolipoprotein-E-Genotyps bei der Alzheimer-Krankheit
(2012-04-04)Alzheimer's Disease is a severe neurodegenerative disorder and the most common of the worldwide 24 million cases. The characteristics are, besides the clinical manifestation, neuropathological hallmarks like deposits ... -
Die Funktionsanalyse und Pharmakomodulation des Amyloid-Vorläufer-Proteins (APP) in vitro und in vivo - Eine neue Zielstruktur zur Behandlung maligner Tumore
(2012-02-28)The ß-amyloid precursor protein (APP) represents a type I transmembrane glycoprotein that is ubiquitously expressed in neuronal as well as in non-neuronal cells. In brain it is a key player ... -
Analyse der Proteinexpression zur Untersuchung der physiologischen Funktion des zellulären Prionproteins (PrPc)
(2012-01-04)The definite physiological role of the cellular prion protein (PrPc) remains still unclear. On the one hand there is ample in vitro and in vivo evidence suggesting a neuroprotective role ...