Browsing Human- und Zahnmedizin by Advisor & Referee "Jarry, Hubertus Prof. Dr."
Now showing items 1-20 of 21
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WIN-55,212-2-Therapie in einem Modell für die sporadische Alzheimer Erkrankung
(2022-11-29)With its far-reaching influence on neuroprotection and inflammation, the endocannabinoid system (ECS) is a promising approach for the therapy of Alzheimer's disease (AD). WIN-55,212-2 (WIN) is a synthetic cannabinoid and ... -
Auswirkungen einer Therapie mit dem nicht-steroidalen Androgenrezeptormodulator Ligandrol auf die Skelettmuskulatur im ovarektomierten Rattenmodell
(2022-09-15)Sarcopenia denotes a syndrome that is characterized by a progressive loss of skeletal muscle mass and strength and is associated with unfavourable outcomes including death. This generalized form of skeletal muscle atrophy ... -
Die Wirkung des selektiven Androgenrezeptor-Modulators Ligandrol auf das Knochengewebe der Tibia am osteoporotischen Rattenmodell
(2021-04-12)In an aging society the number of women affected by osteoporosis will increase constantly. Due to the growing number of clinical cases and the associated costs, the socioeconomic significance of osteoporosis in our society ... -
Speziesunterschiede im organischen Kationentransporter OCT1: Vergleich der Effekte der Aminosäuren F159, W217 und D474 in OCT1 des Menschen, der Maus und der Ratte
(2020-11-26)OCT1 is an integral membrane transporter that is able to transport certain substrates with cationic components in the molecular structure across the plasma membrane of cells. This transporter is important for the human ... -
Studie zur Rolle N-trunkierter Amyloid-β-Peptide bei der Alzheimer-Krankheit
(2019-10-15)Alzheimer’s disease (AD) is a neurodegenerative progressive disease, characterized by extracellular amyloid accumulation, neurofibrillary tangles and neuron loss. N-terminally truncated Aβ4-42 and pyrog ... -
Der Einfluss von Baicalein auf die metaphysäre Frakturheilung im Osteoporosemodell der Ratte
(2019-07-08)The systemic skeletal disease osteoporosis is characterized by reduced bone mineral density and an impairment of the microarchitecture of the bone tissue. The global role of osteoporosis necessitates its classification as ... -
Passive Immunisierung mit einem N-trunkierten Abetaspezifischen Antikörper - Therapeutisches Potential von NT4X in einem familiären Alzheimer-Mausmodell
(2019-03-25)Abstract Alzheimer’s disease is a progressive neurodegenerative illness whose patients suffer from memory loss, problems managing everyday life and increasing helplessness. Worldwide there is a prevalence of over 47 ... -
Retrospektive Analyse historischer Effekte in Kontrollgruppen bei Tierversuchen im Rahmen der Osteoporoseforschung
(2018-07-02)Animal experiments are an important part of medical research. On the other hand, since their application there has been a discussion about the benefits of animal testing in relation to animal rights, animal welfare and ... -
Einfluss der selektiven Inhibition proinflammatorischer Lipoxygenase auf den osteoporotischen Knochen im Ovariektomodell der Ratte
(2018-03-23)Osteoporosis is now a serious widespread disease in Germany. Since the population aged and health care costs continuously increased, the treatment of osteoporosis poses a major socio-economic challenge for society. Established ... -
Vergleichende In-Vivo- und In-Vitro-Untersuchungen zur Bestimmung der CYP1A1-Aktivitätsveränderung durch hormonell aktive Stoffe
(2015-05-15)In numerous studies adressing the impacts of environmental chemicals and particularly endocrine disruptors on human health different mechanisms of interaction between the ERα- and AhR-signal transduction pathway as so-called ... -
Charakterisierung östrogener Effekte von Genistein im Modell der langzeitovarektomierten Maus
(2014-10-14)In recent years, phytoestrogens increasingly gained attention in the field of medical science, as they represent a potential alternative to classical hormone replacement therapy for climacteric affliction, which is is ... -
In-vivo -Monitoring der Effekte von Östrogen, Daidzein und 4-MBC mittels Flächendetektor-Volumen-CT am Modell der ovarektomierten Ratte
(2014-01-14)The study investigated the influence of 4-methylbenzylidene camphor (4-MBC), daidzein, and estradiol-17β-benzoate (E(2)) on either intact or osteotomized cancellous bone in ovariectomized (Ovx) rats. Three-month old Ovx ... -
Localization of the voltage-gated Kv10.2 potassium channel in the mouse organism
(2013-09-10)Already 100 years ago, the importance of ion channels for nerve cell conduction was described. Subsequently, an expression und function of ion channels outside of the nervous system was discovered. Approximately 20 years ... -
Etablierung, Validierung und Anwendung einer gaschromatographisch-massenspektrometrischen Methode zur Analyse von Testosteron und 17α-OH-Progesteron im Serum
(2013-09-03)Objective: The objective of this study was to develop and validate a robust, specific and sensitive electron capture negative ionization gas chromatography-mass spectrometry method (GC-NCI-MS) to quantify serum testosterone ... -
Auswirkungen von Östradiol, Bisphenol A und Octylmethoxycinnamat in östrogen-sensitiven Organen im Langzeitversuch an ovarektomierten Mäusen
(2012-07-04)Introduction: Today our food, drinks etc. are often in contact with chemicals used in the fabrication for packing. More and more consumers are concerned whether these chemicals lead to an accumulation in the organism ... -
Effekte von Calcitriol auf die renale Fibrogenese
(2012-05-11)Calcitriol may decrease extracellular matrix accumulation in animal models of progressive kidney disease. The mechanisms are only partially understood. In order to understand the antifibrotic effects of calcitriol, we ... -
Über die Bedeutung der Zugabe von humanem Serum-Albumin zu exogenen GLP-1-Infusionen am Beispiel der Antagonisierbarkeit des GLP-1 [7-36-Amid]-Einflusses auf die erste Phase der Insulin-Sekretion nach intravenöser Glukosegabe durch den GLP-1-Rezeptor-Antagonisten Exendin [9-39] bei gesunden Menschen
(2011-08-31)Background/aims: Exendin [9-39] has been used as a specific GLP-1 antagonist in order to elucidate the role of endogenously secreted GLP-1 as an incretin. We examined, whether published ... -
Funktionelle Analyse des Prostate-derived-Ets-Factors (PDEF) in der Prostatakarzinomzelllinie LNCaP
(2011-05-09)PDEF a co-regulator of the androgen receptor shows a marked tumour-associated expression. The role of PDEF in cancer cell invasiveness is currently under investigation. To study the function ... -
Östrogenes Potential des endokrinen Disruptors 4-MBC im Reproduktionstrakt von ovariektomierten Ratten
(2011-04-28)4-MBC is an absorber of ultraviolet light which is preferable used as sunscreen. It has been identified as a xenoestrogenic compound supposably by interactions with estrogen receptors (ERs). ... -
Einfluss von Estradiol, Genistein, Equol und Resveratrol auf verschiedene östrogensensitive Organe und Parameter der ovariektomierten Maus
(2011-01-26)Introduction: The effects of estrogen replacement therapy regarding cardioprotective effects remain controversial and attract number of studies that focus on both genomic and non-genomic ...