Blättern Human- und Zahnmedizin nach Betreuer & Gutachter "Oellerich, Michael Prof. Dr. Dr. h.c."
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Beziehungen zwischen Lebensqualität, Verhaltensproblemen und Lipidstoffwechsel bei Jugendlichen
(2018-11-22)Earlier studies in adults have found associations between psychological distress and quality of life as well as serum lipid concentrations. However, no data are available in children and adolescents. In a post-hoc-analysis ... -
Einfluss von Immunsuppression auf das Überleben und im Verlauf nach Lebertransplantation
(2017-06-30)In summary, it can be said that no differences between tacrolimus and sirolimus could be demonstrated in the present study on the development of certain side effects of immunosuppressants after liver transplantation. On ... -
Diagnostische Wertigkeit des Tumormarkers AFP beim hepatozellulären Karzinomrezidiv nach Lebertransplantation
(2017-04-11)Background: Alpha-1-fetoprotein (AFP) is used as tumor marker in a number of clinical settings including recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LTx) but the optimal post liver transplant ... -
Veränderung der Nierenfunktion, des Proteoms und des Phosphorylierungsstatus der Proteine bei Alport-Mäusen unter Mycophenolat-Mofetil
(2016-10-27)Objectives: We aimed to investigate the effects of mycophenolate mofetil (MMF) on kidney function, the proteom and protein phosphorylation in a mouse model for the human Alport syndrome. Methods: COL4A3-deficient (COL4A3-/-) ... -
Die Serumkonzenztrationen von S-100B bei Leberzirrhose und transjugulärem intrahepatischen portosytemischen Stent-Shunt in Abhängigkeit von der minimalen hepatischen Enzephalopathie der Leber- und der Nierenfunktion
(2015-02-04)Portal-sytemic encephalopathy is prototypical among neuropsychiatric disorders that fall under the term of Hepatic Encephalopathies. Ammonia toxicity is central to the pathophysiology of portal-systemic encephalopathy, and ... -
Zirkulierende Nukleinsäuren im zellfreien Plasma von LTx-Patienten als Frühmarker einer Schädigung des Spenderorgans
(2014-09-03)My research found that cell-free DNA (cfDNA) derived from the transplanted organ (GcfDNA, graft-derived cell-free DNA) is a clinically promising biomarker for the direct determination of organ damage in the sense of a ... -
Preoperative MELD score as a predictor for post hemihepatectomy complications
(2014-04-23)Background: As diagnostic techniques and surgical outcomes improve, the rate that hemihepatectomy is performed for various indications will continue to rise. Objectives: To explore the preoperative predictors of postoperative ... -
Diagnostik der Tuberkulose - Bedeutung des γ-Interferon-Tests
(2014-03-03)Despite the fact that 14 million individuals suffer from tuberculosis worldwide, diagnosing tuberculosis still remains challenging and time-consuming while the treatment impairs people for a long time. In 2005, Interferon-γ ... -
Neue Biomarker zur Überwachung der zellulären Immunität chronisch-entzündlicher Darmerkrankungen
(2013-05-31)Currently there are no biomarkers which are able to indicate the disease activity or the risk of relapse of chronic inflammatory bowel disease. In this study new biomarkers of immune monitoring were examined for their ... -
Bestimmung von Pentraxin-3 im Blutserum und dessen Bedeutung für Lebererkrankungen
(2013-02-27)The intention of this study was the investigation of pentraxin 3 (PTX3) in blood of people with liver disease. Former studies had already shown that PTX3 can be useful as a rapidly available marker in the pathogenesis of ... -
Die inhibitorische Wirkung des Acylglucuronidmetaboliten der Mycophenolsäure auf die Inosinmonophosphatdehydrogenase Typ II
(2011-12-05)Mycophenolic acid (MPA), a widely used immunosuppressive agent, exerts its pharmakological action through uncompetitive inhibition of inosine monophosphate dehydrogenase type II (IMPDH-II), ... -
Der Einfluss von Mycophenolat-Mofetil (MMF) auf die renale Fibrogenese: Bedeutung für neue therapeutische Ansätze
(2011-02-01)Within the scope of this study, the potential antifibrotic effect of mycophenolate mofetil (MMF) and its active metabolite mycophenolic acid (MPA) were investigated. For this purpose an in ... -
Die Pharmakokinetic von Meropenem bei Patienten mit schweren Infektionen
(2010-08-04)Meropenem is a carbapenem antibiotic with a broad antibacterial spectrum, good tolerability and high penetration into infected tissues. Due to its excellent pharmacokinetic and pharmacodynamic ... -
Erfassung der Veränderung des Schweregrades der Leberzirrhose: Vergleich Child-Pugh- und MELD-Score-Klassifikation
(2010-06-30)Detecting the change in the severity of liver cirrhosis: Comparison Child-Pugh and MELD-score classification Introduction: In patients with liver cirrhosis, the prognosis was determined by ... -
Pharmakokinetik von Doxorubicin: Populationsvariabilität und Einfluss von genetischen Polymorphismen in Membran-Trasportproteinen
(2007-08-02)In this thesis, the impact of genetic polymorphisms of the membrane transporters MDR1, MRP1, MRP2, MRP3 and BCRP on the pharmacokinetics and side effects of doxorubicin of 94 non-pretreated ...