Blättern Human- und Zahnmedizin nach Betreuer & Gutachter "Zeisberg, Elisabeth Prof. Dr."
Anzeige 1-15 von 15
-
Evaluation of the antifibrotic potential of Serelaxin in two experimental models of cardiac fibrogenesis
(2023-08-28)This study is based on the finding that Relaxin was identified in Rln1 gene knockout mice as a naturally occurring regulator of collagen turnover in the heart (Du et al. 2003). Additionally, in a model of spontaneously ... -
In vitro und in vivo Charakterisierung von KAN0438757 als Inhibitor des glykolytischen Enzyms PFKFB3 im kolorektalen Karzinom
(2023-08-01)Background: Colorectal cancer is the third most common cancer and the second leading cause of cancer-associated deaths worldwide. Despite early detection screening methods, approximately 25% of patients already have ... -
Dreifarbige STED-Nanoskopie von Calcium-Freisetzungseinheiten in humanem linksventrikulären Gewebe verschiedener Subtypen hochgradiger Aortenklappenstenose
(2023-07-24)Confocal microscopy and STED nanoscopy of left ventricular myocardial biopsies from patients with severe aortic valve stenosis were used to investigate mechanisms of dysfunctional cardiac remodeling at the cellular and ... -
Hypermethylierte DNA als Biomarker für Herz- und Nierenerkrankungen
(2023-06-28)Chronic kidney diseases are an increasing medical challenge. Based on the pathophysiology of fibrogenesis, the progression of chronic kidney disease is often characterised by excessive fibroblast activation and parenchymal ... -
Sezernierte Proteindisulfidisomerase ERp57 als potenziell profibrotischer Faktor in der Nierenschädigung
(2023-04-03)Today many people suffer from chronic kidney diseases (CKD), which often lead to renal fibrosis and kidney failure. For this reason dialysis or renal transplantation often become indispensable to life. There are still ... -
Epigenetische Veränderung von zirkulierender Tumor-DNA im Ethylendiamintetraessigsäure (EDTA)-Plasma von Mammakarzinompatienten
(2021-11-22)This proof-of-concept study with the title “Epigenetic alteration of circulating tumor DNA in the ethylenediaminetetraacetic acid (EDTA) plasma of breast cancer patients” discussed whether hypermethylated gene sequences ... -
Die Rolle von Gse1 in der embryonalen Hämatopoese der Maus
(2021-07-27)Objective: To investigate a possible involvement of the gene KIAA0182 in the pathogenesis of hypoplastic left heart syndrome (HLHS), a knockout mouse was generated for previous studies using the knockout-first strategy for ... -
Characterization of the cardiogenesis in embryos of a Gse-1tm-1a(EUCOMM)Wtsi mouse line
(2021-07-16)HLHS is classified as a cyanotic heart disease, which accounts for 25% of all CHD mortalities. It is the leading cause of death in infants under the age of one year. One human candidate gene called KIAA00182 (Gse-1 in mice) ... -
Epigenetische Suppression von RASAL1 und ATP2A2 als Biomarker und Therapieansatz bei kardialer Fibrogenese
(2020-07-10)Chronic heart diseas constitutes a growing medical challenge on a global scale. It is associated with cardiac fibrosis - the accumulation of extracellular matrix produced by persistently activated fibroblasts. Epigenetic ... -
Expression humaner Angiogenesefaktoren in der Plazenta präeklamptischer Patientinnen
(2020-03-23)Preeclampsia is a disease that can occur during pregnancy after 20 weeks of gestation. It is characterized by cardinal symptoms of hypertension > 140/90 mmHg and proteinuria > 300 mg / 24 h. Since preeclampsia can affect ... -
Etablierung von zirkulierenden DNA-Fragmenten als Biomarker für die klinische Progression einer Herzinsuffizienz mit erhaltener Ejektionsfraktion
(2020-02-21)Chronic heart disease is associated with abberant CpG promoter methylation, mechanistically involved cardiac fibrogenesis. Aberant CpG promoter methylation is equally reflected in corresponding blood samples („liquid ... -
Sekundärprävention und stationärer Verlauf von Patienten mit koronarer Herzerkrankung zwei Jahre nach stationärer Anschlussheilbehandlung
(2018-10-18)BACKGROUND The recently published EUROASPIRE IV study demonstrated that a large majority of coronary patients do not achieve the guideline standards for secondary prevention. High prevalences of persistent smoking, unhealthy ... -
Analyse des antifibrotischen Potenzials der betaadrenergen Signalkaskade und des PKA-Effektors Protein-Phosphatase-Inhibitor-1
(2017-05-17)The fibrotic remodeling of the heart appears in several cardiac diseases. Especially fibroblasts, which are known as the tissue producing cells in the heart, contribute to this process. Interacting with cardiomyocytes they ... -
‘Knockout-first’ mouse model as a biological tool to study the role of KIAA0182 gene in hypoplastic left heart syndrome
(2016-03-08)Objective: Hypoplastic left heart syndrome (HLHS) is one of the most severe congenital heart diseases. The genetic etiology for this syndrome was strongly suggested by several previous studies, and a lot of genes were ... -
Wirkung von zwei verschieden konzentrierten alkoholfreien CHX-Mundspüllösungen auf die Regenerationsfähigkeit von humanen Gingivafibroblasten
(2014-02-17)Increasing importance is given to the antiseptic, anti-inflammatory and tooth protec-tion properties of chlorhexidine mouth washes, as the mechanical plaque reduction is often insufficient. Numerous studies have proven ...