Blättern Human- und Zahnmedizin nach "Groß, Uwe Prof. Dr." Betreuer
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Korrelation der 5-Flucytosin-Resistenz in Candida albicans mit Markerpeak im MALDI-Massenspektrum durch neue Extraktionsmethode
(2024-03-06)Candida albicans is a facultative pathogenic fungus that occurs worldwide and is found in the gastrointestinal tract of the majority of people. In immunocompromised patients, however, it can lead to severe systemic infections. ... -
Verbesserung der MALDI-TOF-basierten Identifizierung humanpathogener Pilze durch die Erstellung individueller Datenbanken
(2023-12-12)The identification of rare fungal species using MALDI-TOF mass spectrometry is limited by the fact that commercial databases are incomplete or the preparation protocols in routine diagnostics are complex. This dissertation, ... -
Eine vergleichende Studie der mikrobiellen Hautflora und der bakteriellen Ursachen von Durchfall bei Kindern in städtischen und ländlichen Gemeinden in Indonesien
(2023-11-17)Dieser Arbeit ist die Hypothese vorausgesetzt, dass in Indonesien Enterobacteriaceae einschließlich obligater Krankheitserreger wie Salmonellen, Shigellen und Yersinien bei Kindern, die auf dem Land leben, häufiger vorkommen ... -
Inhibitorische Effekte von 1-Hydroxychinolonen auf Toxoplasma gondii
(2023-11-09)Within the mitochondria of Toxoplasma gondii, 1-hydroxyquinolones were identified as affine inhibitors of the alternative NADH-dehydrogenase at the first complex of the respiratory chain. Another target structure of the ... -
Effekt der Carbapenemasen Vim1, Ndm1 und Oxa48 auf die bakterielle Fitness von E. coli K12 MG1655
(2022-09-14)Antibiotic resistance is an important subject in clinic medicine. As part of this doctor's thesis, the effect of three different Carbapenemases Vim1, Ndm1 and Oxa48 on bacterial fitness of E. coli bacteria was examined. ... -
Analyse der antiviralen Aktivität von IFITM-Proteinen
(2022-07-19)Viral infections are among the leading causes of death worldwide. Only a limited number of therapy options are available. Moreover, the high mutation rate of many viruses leads to the rapid development of resistance. In ... -
Entwicklung MALDI-TOF-basierter diagnostischer Methoden zur Identifikation periprothetischer bzw. gelenkassoziierter Infektionen
(2022-07-11)Development MALDI-TOF based diagnostic methods to detect periprothetic or joint associated infections -
Das Wachstums- und Sporulationsverhalten klinischer Clostridioides-difficile-Isolate unter intestinalen Gallensalzkonzentrationen
(2021-11-10)Problem: Clostridioides difficile infections (CDI) have emerged as the leading cause of hospital-acquired diarrhea. The disruption of physiological gut microbiota by consumption of antibiotics is one of the major risk ... -
Phäno- und genotypische Charakterisierung konsekutiver Isolate eines Patienten mit rezidivierenden Clostridium difficile-Infektionen
(2019-03-06)Thirteen C. difficile isolates deriving from recurrent infections of a single patient were isolated during a fifteen-month ongoing course of disease and analyzed regarding their morphology, phenotype and genotype. The ... -
The Social Impact of HIV-Seropositivity and Antiretroviral Treatment on Women in Tanga, Tanzania. A Qualitative Study.
(2017-11-13)With access to highly active antiretroviral therapy (ART) for HIV-seropositive patients a positive change in the perception of the disease was anticipated, leading to a reduction in discrimination and stigmatization and ... -
Prevalence of infectious risk factors during pregnancy: An infectiological snapshot of 180 pregnant women in a rural setting of Western Ghana
(2017-03-03)Prevalence of infectious risk factors during pregnancy: An infectiological snapshot of 180 pregnant women in a rural setting of Western Ghana A cross-sectional pilot study in a rural area of Western Ghana was carried out ... -
Epidemiology and prevalence of oral candidiasis in HIV patients from Chad
(2016-03-03)The study was performed to determine the prevalence and epidemiology of oral candidiasis among HIV-positive patients in Chad and evaluate the susceptibility of the yeasts found in the oral cavity to five antifungals. The ... -
Vergleichende Untersuchungen der Nasenflora von Probanden aus Ghana und Deutschland
(2015-08-12)Purpose: This study aims at comparing the composition and resistance patterns of nasal flora by analyzing swab samples of subjects living in rural Ghana and subjects living in Germany. Special attention is paid to the ... -
Epidemiologie Virulenz-assoziierter Markergene in Campylobacter jejuni-Subpopulationen
(2014-10-01)Thermophilic C. jejuni is one of the most common causes of bacterial gastroenteritis in humans worldwide. The pathogen is transmitted mainly through cross-contaminated food, mostly originating from poultry products. C. ... -
Zur Bedeutung von Plasmiden für die Pathogenität von Campylobacter jejuni
(2012-11-08)Campylobacter jejuni is one of the most common causes of bacterial diarrhoe in humans. We examined the influence of plasmids in the ability of isogenic bacterial strains of C.jejuni to infect intestinal human caco2-cells ... -
Vergleichende epidemiologische Untersuchungen zur bakteriellen Genese von Fieber unklarer Ursache in Ghana
(2012-05-29)Bacterial distribution and antimicrobial drug resistance were monitored in patients with bacterial bloodstream infections in rural hospitals in Ghana. In 2001–2002 and in 2009, Salmonella enterica serovar Typhi was the ... -
Optimierung der molekularbiologischen Diagnostik systemischer Mykosen
(2012-05-15)The rapid and efficient diagnosis of systemic fungal infections is essential for an effective therapeutic regimen of frequent immunosuppressed patient population. For this purpose, the PCR method offers a good diagnostic ... -
Assoziation von Genvarianten aus der Chromosomenregion 5q31-33 mit der Inzidenz von Malaria und Anämie bei Kindern aus Ghana
(2011-11-17)In this work, the 5q31-33 chromosomal region was investigated for genetic associations with the incidence of malaria and anemia in children from Ghana.Variants of the genes interleukin 4 ... -
Stamm- und wirtszellabhängige Apoptose-Induktion durch Campylobacter jejuni
(2011-11-04)At present Campylobacter jejuni is the numerically most important pathogenic agent of enteritis in Germany. The suspected main toxin of the organism is the Cytolethal distending toxin (Cdt), ... -
Identifizierung und Charakterisierung des Effektorproteins CPn1020 von <i>Chlamydophila pneumoniae</i>
(2006-08-08)Chlamydophila pneumoniae is an obligate intracellular bacterial pathogen of acute respiratory tract infections, responsible for about 10 % of community acquired pneumonia cases worldwide. ...