Browsing Human- und Zahnmedizin by Advisor "Legler, Tobias Prof. Dr."
Now showing items 1-8 of 8
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Dendritisches Polyglycerolsulfat als neues Therapeutikum der akuten GvHD
(2024-04-26)Despite decades of research, acute GvHD (aGvHD) remains to be one of the leading causes of increased mortality and morbidity for patients following stem cell transplantation. Due to the limited therapeutic options for the ... -
Modifikation und Analyse der allogenen extrakorporalen Photopherese im Mausmodell der Graft-versus-Host Disease
(2023-01-31)Extracorporeal photopheresis (ECP) is a well-established and well tolerated second line therapy in graft-versus-host disease (GvHD), a major cause of high morbidity and mortality after a hematopoietic stem cell transplantation. ... -
Extrakorporale Photopherese mit UVC-behandelten Leukozyten im Vergleich zu 8-MOP/UVA-behandelten Leukozyten zur Therapie der akuten graft-versus-host disease im Mausmodell
(2022-02-28)Graft-versus-host disease (GvHD) is a complication after allogeneic hematopoietic stem cell transplantation and responsible for the high morbidity and mortality rate. Extracorporeal photopheresis (ECP) is a common second-line ... -
Epigenetische Veränderung von zirkulierender Tumor-DNA im Ethylendiamintetraessigsäure (EDTA)-Plasma von Mammakarzinompatienten
(2021-11-22)This proof-of-concept study with the title “Epigenetic alteration of circulating tumor DNA in the ethylenediaminetetraacetic acid (EDTA) plasma of breast cancer patients” discussed whether hypermethylated gene sequences ... -
Niedermolekulares und unfraktioniertes Heparin als Therapeutika der akuten Graft-versus-Host Disease im Mausmodell
(2021-11-09)Acute graft-versus-host disease (aGvHD) is a common complication after allogeneic hematopoietic stem cell transplantation for which only limited therapeutic options are available. Numerous published studies have shown an ... -
UVC als Alternative zur 8-MOP / UVA-Behandlung in der extrakorporalen Photopherese
(2020-02-07)Background Graft-versus host complications and other (auto-)immune diseases are successfully treated with Extracorporeal Photopheresis (ECP), a widely accepted cellular therapy. The international standard for the ex vivo ... -
Inhibition des microRNA-Clusters 17-92 als mögliche Leukämietherapie
(2017-09-29)The dysregulation of microRNAs appears to be a crucial factor in leukemia. Therefore, therapies might be possible that target the altered expression of proliferation-regulating microRNAs. The microRNA cluster 17-92 was ... -
Etablierung eines Verfahrens zum Nachweis epigenetischer Biomarker im peripheren Blut zur Stratifizierung der Therapie des Rektumkarzinoms
(2015-12-08)Bisulfite treatment based assays are mainly used to detect aberrant, tumor specific methylation of specific DNA regions either from tissue or from free circulating DNA in plasma or serum. Since bisulfate based protocols ...