Browsing Human- und Zahnmedizin by Advisor "Reichardt, Holger Prof. Dr."
Now showing items 1-7 of 7
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Klonierung und Expression einer extrazellulären Lipase von A. fumigatus
(2012-05-15)In Germany every year a great number of people contract invasive mould mycosis initiated by the fungus Aspergillus fumigatus. Almost solely severe immunocompromised patients are being affected. The infection with A. fumigatus ... -
Neuartige Wirkmechanismen und Therapiestrategien von Glukokortikoiden in der Behandlung von Multipler Sklerose im Tiermodell
(2014-06-24)Despite the enormous progress being made in the development of new therapies, such as monoclonal antibodies, GCs are still one of the best options available to treat inflammatory diseases. One of the main drawbacks of this ... -
Prädiktive Biomarker für die Entwicklung von high grade acute organ toxicity im Rahmen der Radiochemotherapie bei Patienten mit Kopf-Hals-Tumoren
(2017-11-22)The treatment of head and neck cancers by radiochemotherapy often leads to high grade acute organ toxicity (HGAOT). These side effects impair the patients’ quality of life as well as the local tumor control as they can ... -
Role of the glucocorticoid receptor in the development of ulcerative colitis and colorectal carcinoma in a murine model
(2022-08-29)For many decades, glucocorticoids (GCs) have been an essential pillar of the therapy of many inflammatory diseases. The beneficial effects of this class of hormones occur quickly and reliably after administration, although ... -
Die Rolle des antiapoptotischen Gens Gimap5 für die Pathogenese neuroinflammatorischer Erkrankungen
(2017-11-06)T-cell lymphopenia is a major risk factor for autoimmunity. A loss-of-function mutation in the Gimap5 gene leads to a reduction in peripheral T-cell numbers in Congenic Lewis rats. Gimap5-deficient Lewis rats developed ... -
Die Rolle des Glukokortikoid-Rezeptors bei der Colitis Ulcerosa im Mausmodell
(2022-09-20)Chronic inflammatory bowel diseases such as ulcerative colitis are widespread diseases that significantly reduce the quality of life of those affected by symptoms such as abdominal pain, diarrhea and weight loss. In addition, ... -
Untersuchungen zur Pathogenese und Therapie der Notch1-abhängigen T-ALL in einem transgenen Rattenmodell.
(2016-10-25)Acute T lymphoblastic leukemia/lymphoma (T-ALL) is an aggressive cancer with high recurrence rate and poor prognosis. Dysregulated Notch signaling accounts for the majority of T-ALL cases in humans. Despite of the important ...