Browsing Human- und Zahnmedizin by Referee "Bayer, Thomas A. Prof. Dr."
Now showing items 1-17 of 17
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Der Einfluss von Aβ4-42 auf die Kognition und die Anwendung von Suchstrategien im Morris Water Maze im Tg4-42-Mausmodell
(2024-03-25)The relevance of Alzheimer's dementia for our society is increasing. Soluble amyloid beta (Aβ) plays a particularly important role in the genesis of this disease. Aβ4-42 in particular, which is truncated before the fourth ... -
The role of Neuroligin-2 in fear circuits
(2023-01-02)In the past decades, strong evidence arose that the emergence of a large variety of neuropsychiatric conditions is caused by perturbations of the synaptic transmission on the molecular level. The synapse is the key structure ... -
Modulation der synaptischen Plastizität im Rett-Syndrom durch Antioxidantien-Fütterung
(2021-10-05)Rett syndrome is a severe neurodevelopmental disorder that almost exclusively affects females. Upon an apparently normal development during the first 6 – 18 months of life, developmental stagnation and especially neurological ... -
Auswirkung der TLR4-Inhibition bei verschiedenen Applikationswegen im Modell des ischämischen Schlaganfalls
(2020-11-10)Stroke is one of the most common diseases today and one of the leading causes for physical and psychological disability. Except of the recanalisation therapies that have been established there are no other therapeutical ... -
Beurteilung des therapeutischen Potenzials von intraperitoneal injiziertem Metallothionein-II im ischämischen Schlaganfallmodell an der Maus
(2019-02-25)All across the globe ischemic strokes are one of the prime contributors to death as well as physical and psychological disability. Even though prospects for therapeutic treatment during the acute phase have experienced ... -
Neuropathological and behavioral alterations in two transgenic mouse models of Alzheimer´s disease
(2016-07-05)According to the influential amyloid cascade hypothesis cerebral accumulation of Aβ is the key event in the pathogenesis of Alzheimer´s disease. Aβ deposits occur as soluble forms, as well as insoluble forms. It is assumed ... -
Therapeutisches Potenzial und Langzeiteffekt der TLR4-Inhibition bei der fokalen zerebralen Ischämie
(2016-04-11)Ischemic stroke is known to be one of the leading causes of death worldwide. As therapeutic options especially for treatment beyond 4,5 to 6 hours after the beginning of symptoms are limited, recent studies have focussed ... -
Die Rolle der Beta-Sekretase bei der Myelinisierung im Zentralen Nervensystem
(2014-04-15)BACE1, the beta-secretase, plays a significant role in the formation of amyloid, a histopathological hallmark of Alzheimer's Disease. The physiological function of BACE1 remains unclear. Recent studies showed a role in ... -
Localization of the voltage-gated Kv10.2 potassium channel in the mouse organism
(2013-09-10)Already 100 years ago, the importance of ion channels for nerve cell conduction was described. Subsequently, an expression und function of ion channels outside of the nervous system was discovered. Approximately 20 years ... -
Einfluss einer intrazerebralen Infektion mit Escherichia coli auf den Verlauf der Alzheimer-Demenz im Mausmodell
(2013-06-24)Bacterial infections often worsen the existing neurological symptoms of patients with neurodegenerative diseases such as Alzheimer´s disease. Not only the acute consequences in the sense of a delirium but also the long-term ... -
Role of amyloid beta protein modulation in Alzheimer's disease
(2012-07-17)Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly. It is mainly characterized by the deposition of amyloid plaques and neurofibrillary tangles. In addition, inflammatory processes in ... -
Analyse der Proteinexpression zur Untersuchung der physiologischen Funktion des zellulären Prionproteins (PrPc)
(2012-01-04)The definite physiological role of the cellular prion protein (PrPc) remains still unclear. On the one hand there is ample in vitro and in vivo evidence suggesting a neuroprotective role ... -
Estimating Chronic Wasting Disease infectivity in cell culture
(2011-11-14)The rapid spread and high prevalence of CWD in North American cervids have raised concerns about a potential risk to human health. Experimental transmission of CWD to various species has ... -
Neuropathologische und verhaltensbiologische Untersuchungen an transgenen Alzheimer-Mausmodellen bezüglich des Angstverhaltens
(2011-06-29)Multiple studies have shown that there is a high prevalence of anxiety disorders and depression in patients with Alzheimer`s disease. An altered anxiety behaviour has also been observed in ... -
Exosomes act as molecular vehicles contributing to cellular cholesterol efflux
(2011-02-11)Exosomes are small vesicles of 50-100 nm diameter that derive from intraluminal vesicles (ILVs) and are secreted into the extracellular environment upon fusion of multiversicular bodies ... -
Untersuchung genetischer und geschlechtlicher Einflüsse in der Alzheimerpathologie anhand des Maustiermodells 5XFAD
(2010-10-27)The Alzheimer´s Disease is the most frequent dementia. In Germany are approximately 900.000 individuals affected. Although there are great efforts to investigate the pathogenesis, there is ... -
Transthyretin-, Aß 1-40- und Aß 1-42- und Tau-Protein-Konzentrationen im Liquor cerebrospinalis bei demenziellen Erkrankungen
(2010-10-11)In this dissertation levels of transthyretin, tau protein and amyloid beta peptide (1-40 and 1-42) were measured in the cerebrospinal fluid of 106 patients with different forms of dementia ...