Browsing Human- und Zahnmedizin by Referee "Brück, Wolfgang Prof. Dr."
Now showing items 1-20 of 22
-
From the morphological to the integrated diagnosis of diffuse gliomas – a retrospective study
(2023-08-03)From the first classification of brain tumors by Rudolf Virchow in 1863 to our most recent WHO 2016 Classification, more than 150 years have passed. Within that time period, our understanding and scientific progress has ... -
Charakterisierung von Peroxiredoxin 2 im zentralen Nervensystem bei Multipler Sklerose
(2021-10-21)Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, characterized by demyelination and axonal damage as well as neuronal degeneration. Oxygen-derived free radicals are an important ... -
Die Effekte des Wlds-Gens und der Gabe von Nikotinamid auf akute und chronisch-sekundäre Axon-Degeneration
(2021-07-21)Charcot-Marie-Tooth disease (CMT) is the most common inherited neuropathy and a duplication of the peripheral myelin protein of 22 kDa (PMP22) gene causes the most frequent subform CMT1A. Clinical impairments are determined ... -
One-carbon metabolism in lung cancer
(2020-10-26)One-carbon metabolism (1CM) plays a central role in cell proliferation and an elevated activity is accounted for the progression of several cancer types. Increased 1CM is a known risk factor for lung cancer and the anti-folate ... -
Urokinase-type plasminogen activator receptor contributes to chemosensitivity and epithelial-to-mesenchymal transition in PDAC
(2020-10-26)Purpose: Pancreatic ductal adenocarcinoma (PDAC) is the most frequent maliganancy of the pancreas and the fourth most lethal cancer with a 5-year overall survival rate of < 5 %. Patients with a gene amplification in the ... -
Histologische Charakterisierung der Leukodystrophien und deren differentialdiagnostische Abgrenzung
(2020-02-07)Introduction Leukodystrophies (LDs) describe a class of various diseases of the white matter caused by genetic defects leading to a disturbed myelination. In our study we defined histologic characteristics of various Lds ... -
Untersuchungen zur Rolle des Silent information regulator 2 (Sirt2) im experimentellen Schlaganfall in Mäusen
(2019-07-22)Sirtuin-2 (Sirt2) is a member of the NAD+-dependent protein deacetylase family. Various members of the sirtuin class have been found to be involved in processes related to longevity, regulation of inflammation, and ... -
Immunologische und molekulare Profile von "smoldering lesions" der Multiplen Sklerose
(2017-05-18)Multiple sclerosis (MS) is a chronic-inflammatory disease of the central nervous system. It is characterized by progressive demyelination for which no effective therapy has yet been established. Characteristics of the ... -
Untersuchungen zur Pathogenese subpialer kortikaler Läsionen bei Multipler Sklerose und bei Marmosetten mit experimenteller autoimmuner Enzephalomyelitis
(2015-06-30)Lately, evidence has accumulated the extensive grey matter involvement in multiple sclerosis (MS). It is known that subpial cortical demyelination (SCD) accounts for the greatest proportion of demyelinated cortex in ... -
MicroRNA-Regulation in experimenteller autoimmuner Enzephalomyelitis im Vergleich mit Multiple Sklerose-Läsionen
(2014-09-08)Multiple sclerosis (MS) is the most common chronic inflammatory disease of the central nervous system and the most common cause of acquired disability in young adults. Histopathological hallmarks of MS are focal lesions ... -
Quantitative Untersuchung der subkortikalen Neurone im Multiple-Sklerose-Modell der experimentellen autoimmunen Enzephalomyelitis bei Callithrix-jacchus-Marmosetten
(2014-01-14)The general aim of this study was to investigate the densitiy of white matter neurons in marmosets with MOG-induced experimental autoimmune encephalomyelitis (EAE). The specific aim was to see whether there was an increase ... -
Quantitative Untersuchung der Oligodendrozytendichte im Kortex von Callithrix-jacchus Marmosetten mit Experimenteller Autoimmuner Enzephalomyelitis
(2013-11-01)Histopathological studies of Multiple sclerosis (MS) are usually limited by the fact that autopsy tissue is usually from patients in the chronic stage of the disease. Thus far there are only few results on the pathology ... -
Die Auswirkung von verschiedenen Proteasom-Inhibitoren auf die Wallersche Degeneration peripherer Nerven in vitro und in vivo
(2013-08-06)The present study examined the effects of proteasome inhibitors on Wallerian degeneration (WD) in the peripheral nervous system on the example of sciatic nerve sectioning in vivo and on the basis of nerve-macrophage ... -
Das lymphozytäre Entzündungsinfiltrat in Multiple-Sklerose-Läsionen: Immunhistochemische Analyse im Bezug auf immunopathogenetische Subtypen und Läsionsaktivitäten
(2012-06-21)Multiple sclerosis is a chronic inflammatory demyelinating disease of the CNS. The heterogeneity of the disease is reflected in different immunopathological patterns. Aim of the study is the examination of lymphocytes ... -
Therapie der experimentellen autoimmunen Enzephalomyelitis mit Mitoxantron - Vergleichende Analyse von C57BL/6J- mit Abcg2-knock-out-Mäusen
(2012-03-16)Mutiple sclerosis defines the most frequent neurological disease of young adults. It is a complexe disease with mostly unknown etiology and no effective cure. Studies in experimental ... -
Stickoxidmetabolite als Ursache einer differentiellen Myelingenexpression in MS-Läsionen?
(2011-10-18)Nitric oxide metabolites: the cause of dysregulation of myelin protein genes in multiple sclerosis lesions? Actively demyelinating multiple sclerosis lesions are histologically characterized ... -
Reaktive Astrozytenveränderungen in Multiple-Sklerose-Läsionen: Morphologische und immunhistochemische Analyse unter Berücksichtigung verschiedener Läsionsaktivitäten und immunpathologischer Subtypen
(2011-06-15)Multiple sclerosis (MS) is a heterogeneous disease characterized by demyelination, inflammation, axonal loss, and astrogliosis. However, the role of astrocytes in the pathogenesis of MS ... -
Multiple Sklerose: Einflussfaktoren von Oligodendrozytendichte und Remyelinisierung, Östrogen und Progesteron als Protektiva?
(2011-05-31)During the last decade it became more and more apparent that MS is not only clinically but also histologically a heterogeneous disease. It seems now likely that a primary oligodendroglial ... -
Pathologische Veränderungen im Thalamus in einem Tiermodell für die Alzheimer-Krankheit
(2010-09-14)The accumulation of beta-amyloid (A beta) plaques and neurofibrillary tangles consisting of hyperphosphorylated tau protein are pathological features of Alzheimer's disease (AD) commonly ... -
Das zelluläre Prionprotein im Liquor cerebrospinalis von Patienten mit verschiedenen neurologischen Erkrankungen
(2010-09-13)We performed a study on levels of the cellular prion protein (PrPc) in humans affected by different neurological diseases and assessed the influence of several factors such as age, gender, ...